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Effects of L. Bract Extract on Lipid Metabolism Disorders Through Modulation of HMG-CoA Reductase, Apo A-1, PCSK-9, p-AMPK, SREBP-2, and CYP2E1 Expression.
Metabolites
December 2024
Laboratory of Bioresources, Biotechnologies, Ethnopharmacology and Health, Faculty of Sciences, University Mohamed I, Oujda 60000, Morocco.
Hyperlipidemia is a major contributor to metabolic complications and tissue damage, leading to conditions such as liver steatosis, atherosclerosis, and obesity. This study aimed to investigate the effects of aqueous artichoke bract extract (AE) on lipid metabolism, liver antioxidative defense, and liver steatosis in mice fed a high-fat, high-sucrose diet while elucidating the underlying mechanisms. An 8-week study used hyperlipidemic mice treated with AE at daily doses of 100 and 200 mg/kg bw, compared to fenofibrate.
View Article and Find Full Text PDFTemporal trends in gender, etiology, severity and outcomes of acute pancreatitis in a third-tier Chinese city from 2013 to 2021.
Ann Med
December 2025
Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Article Synopsis
- The study analyzed data from 2013 to 2021 on patients with acute pancreatitis (AP) in a Chinese city, revealing an increase in cases linked to hypertriglyceridemia and alcohol consumption while the prevalence of biliary-related AP remained stable.
- An increase in severe acute pancreatitis (SAP) cases was noted, with a rise in prevalence from 4.97% to 12.2% over the years, and male patients were found to have a higher occurrence of AP compared to females.
- Additionally, the median length of stay and hospitalization costs significantly decreased, while the overall in-hospital mortality rate remained constant throughout the study period.
Magnetic resonance imaging (MRI) and clinical features of different parts of the pancreas involved in acute pancreatitis: a cross-sectional study.
Quant Imaging Med Surg
December 2024
Medical Imaging Key Laboratory of Sichuan Province, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Background: Patients with acute pancreatitis (AP) have different sites of pancreatic involvement. The aim of this study was to investigate the differences in magnetic resonance imaging (MRI) findings and clinical features of different sites of involvement (subtypes) in AP, with a view to complement and complete the classification of AP based on anatomical imaging features.
Methods: We consecutively collected data from inpatients with AP from January 2018 to October 2022 at a tertiary care hospital.
Global Epidemiology of Hepatocellular Carcinoma.
J Clin Exp Hepatol
October 2024
Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
Article Synopsis
- * The incidence of HCC varies significantly worldwide, with the highest rates in East Asia and sub-Saharan Africa due to the prevalence of hepatitis B and C viruses, while rising cases in Western countries are associated with increasing alcohol abuse and metabolic issues like steatosis liver disease.
- * Prevention strategies differ by region and emphasize vaccination against hepatitis B, antiviral treatments, moderation of alcohol consumption, and lifestyle changes to tackle obesity and reduce the risk of MASLD-related HCC.
Pemafibrate for treating MASLD complicated by hypertriglyceridaemia: a multicentre, open-label, randomised controlled trial study protocol.
BMJ Open
November 2024
Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine Graduate School of Medicine, Yokohama, Kanagawa, Japan
Introduction: Non-alcoholic fatty liver disease, now known as metabolic dysfunction-associated steatotic liver disease (MASLD), is a phenotype of the metabolic syndrome in the liver and is clearly associated with metabolic abnormalities such as hyperglycaemia and dyslipidaemia. Although the prevalence of MASLD is increasing worldwide, there is currently no consensus on the efficacy and safety of the drugs used to treat MASLD/metabolic dysfunction-associated steatohepatitis (MASH). Pemafibrate, a selective peroxisome proliferator-activated receptor alpha modulator, was designed to have higher peroxisome proliferator-activated receptor alfa (PPARα) agonist activity and selectivity than existing PPARα agonists, and in development trials, without increasing creatinine levels, lipid parameters and alanine aminotransferase (ALT) were significantly improved.
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