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Clinical Characteristics and Laboratory Diagnoses of Pediatric Patients Hospitalized During an Outbreak of Mycoplasma pneumoniae.
APMIS
January 2025
Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
This study prospectively collected the clinical data, information on respiratory pathogens, and laboratory findings of children with Mycoplasma pneumoniae (M. pneumonia) infection who were hospitalized at the First Affiliated Hospital of Anhui Medical University during the M. pneumoniae outbreak in Hefei City, Anhui Province, China, between October 2023 and December 2023.
View Article and Find Full Text PDFComparative analysis of brain volumetric measurements between contrast-enhanced and non-contrast MRI images.
Neurosci Lett
January 2025
Max Super Speciality Hospital, Saket, New Delhi, India. Electronic address:
Background: Clinical brain MRI scans, including contrast-enhanced (CE-MR) images, represent an underutilized resource for neuroscience research due to technical heterogeneity.
Purpose: To evaluate the reliability of morphometric measurements from CE-MR scans compared to non-contrast MR (NC-MR) scans in normal individuals.
Methods: T1-weighted CE-MR and NC-MR scans from 59 normal participants (aged 21-73 years) were compared using CAT12 and SynthSeg + segmentation tools.
High-throughput determination of exchange rates of unmodified and PTM-containing peptides using HX-MS.
Mol Cell Proteomics
January 2025
Broad Institute of MIT & Harvard, Cambridge, MA. Electronic address:
Despite the widespread use of MS for hydrogen/deuterium exchange measurements, no systematic, large-scale study has been conducted to compare the observed exchange rates in protein-derived, unstructured peptides measured by MS to the predicted exchange rates calculated from NMR-derived values and how neighboring residues and post-translational modifications influence those exchange rates. In this study, we sought to test the accuracy of predicted values by performing hydrogen exchange measurements on whole cell digests to generate an unbiased dataset of 563 unique peptides derived from naturally-occurring protein sequences. A remarkable 97% of observed exchange rates of peptides are within two-fold of predicted values.
View Article and Find Full Text PDFFoveal Avascular Zone development by OCTA: weighing the influence of Gestational Age and neonatal early growth independently of Retinopathy of Prematurity.
Retina
December 2024
Pediatrics Department. Alvaro Cunqueiro University Hospital, 36313 Vigo, Spain. Galicia Sur Health Research Institute.
Purpose: Focusing the premature birth and its potential complications, this study analyzes Foveal Avascular Zone (FAZ) measured by Optical Coherence Tomography Angiography (OCTA) and its correlation with the severity of prematurity and neonatal growth.
Methods: A cross-sectional comparative study was performed, involving 71 children school-age with history of prematurity and a full-term children control group. Several variables from the neonatal period were collected, such as Gestational Age (GA), Birth Weight (BW), initial Weight Gain (WG) and Retinopathy of Prematurity (ROP).
Simulation of the biocide distribution in soil using PELMO coupled with COMLEAM.
Environ Sci Pollut Res Int
January 2025
Institute for Bioanalysis, University of Applied Sciences Coburg, Coburg, Germany.
Biocides, applied in building materials as antimicrobial protectants, can be leached out by rain, presenting substantial environmental risks as confirmed by studies on aquatic environments. However, these biocides are consistently released throughout the year in a diluted form, posing unique challenges for the prediction of transport, transformation, and ecotoxicity assessment in soil. To address this challenge, we combined COMLEAM, which predicts leaching from facades into the soil, with the FOCUS PELMO pesticide model to predict biocide distribution in soil.
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