Targeting chromatin regulators for the treatment of malignancies has shown great promise, but also revealed significant challenges. By employing an elegant shRNA screen and a selective pharmacological inhibitor, a recent study published in Nature establishes the bromodomain protein Brd4 as novel target in acute myeloid leukemia (AML).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659823 | PMC |
| http://dx.doi.org/10.1016/j.ccr.2011.08.019 | DOI Listing |
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