AI Article Synopsis
- The study aimed to assess the prevalence and impact of the AES-1 strain of Pseudomonas aeruginosa in a pediatric cystic fibrosis center implementing cohort segregation.
- The analysis of prevalence showed a significant decline from 21% in 1999 to 6% in 2007, indicating that cohort segregation effectively reduced new infections.
- Additionally, 69% of deaths during the study period were linked to AES-1 infections, highlighting the strain's severity and the need for continued monitoring in cystic fibrosis patients.
Article Abstract
Aim: To evaluate changes in prevalence of an epidemic strain of Pseudomonas aeruginosa (AES-1, Australian epidemic strain, type 1) in a paediatric cystic fibrosis (CF) centre practising cohort segregation, to describe the patients' clinical characteristics at acquisition and observe mortality rates.
Methods: Cohort segregation was introduced in our paediatric CF clinic January 2000. The prevalence of AES-1 was analysed in 1999, 2002 and 2007. Age at acquisition, lung function, presence of bronchiectasis, hospitalisations, prior P. aeruginosa infection and mortality rates were collected. AES-1 infection was determined by pulse-field-gel-electrophoresis (PFGE) on airway specimen cultures taken three monthly.
Results: The prevalence of AES-1 declined from 21% in 1999 to 14% in 2002 (risk difference 7% (95% CI 1,13) p=0.0256) and to 6% in 2007 (risk difference 8% (95% CI 3,13) p=0.0018). New acquisitions after the introduction of cohort segregation were uncommon (10 by 2002 and another 7 by 2007) with a declining incidence of 3.3 cases/year (1999 to 2002) compared to 1.4 cases/year (2002 to 2007). Twenty-two of 32 (69%) deaths between 1999 and 2007 occurred in patients infected with AES-1.
Conclusion: Cohort segregation has been associated with reductions in the prevalence of AES-1 in our CF clinic. Mortality was higher in patients infected with AES-1 than other organisms.
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| http://dx.doi.org/10.1016/j.jcf.2011.08.005 | DOI Listing |
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