The goals of this study were to determine if the glomerular filtration rate (GFR) in dogs could be estimated by plasma inulin clearance and/or infusion inulin clearance analyses without urine collection, and to compare these results with GFR values obtained by urinary inulin clearance analysis. The dogs included in this study were healthy 20 beagles. Inulin clearance values were obtained by urinary inulin clearance, infusion inulin clearance, and plasma inulin clearance techniques. Urinary inulin clearance was 4.09±0.52 ml min(-1) kg(-1) (body weight); infusion inulin clearance, 4.01±0.49 ml min(-1) kg(-1); and plasma inulin clearance, 4.14±0.66 ml min(-1) kg(-1). The urinary inulin clearance was strongly correlated with infusion inulin clearance and weakly correlated with plasma inulin clearance. The GFR for dogs can be estimated by infusion and plasma inulin clearance analyses by blood sampling alone, without urine collection.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.rvsc.2011.08.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Introduction: Glomerular filtration rate (GFR) estimation equations have not been extensively validated in the Indian population. Preliminary data showed that the widely used creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2009 significantly overestimated GFR in Indians. Newer estimated GFR (eGFR) equations based on creatinine and cystatin C, omitting the race, have been recently proposed.
View Article and Find Full Text PDFEssential oil supplementation improves insulin sensitivity and modulates the plasma metabolome of hyperinsulinemic horses.
Front Vet Sci
December 2024
Department of Animal and Food Sciences, University of Kentucky, Lexington, KY, United States.
The objective of this study was to investigate the effect of essential oil (EO) supplementation on insulin sensitivity (IS) and the plasma metabolome in insulin dysregulated (ID) horses. Horses were blocked by degree of IS and assigned randomly to treatment: oral daily bolus (50 mL) of either a plant derived EO supplement or carrier (CON). Mares were housed in dry lots with access to grass hay and supplemented individually twice daily with a concentrate to meet nutrient requirements for mature horses.
View Article and Find Full Text PDFDefinition of hyperfiltration taking into account age-related decline in renal function in kidney donor candidates with obesity and glucose tolerance disorder.
Hypertens Res
December 2024
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
The definition of hyperfiltration, the main pathogenesis in renal impairment in obesity and diabetes mellitus, is uncertain. Glomerular filtration rate (GFR) declines physiologically with aging, and there is inaccuracy in GFR in obesity due to body surface area (BSA) correction. Here, we defined hyperfiltration using GFR without BSA correction, but with inclusion of aging, and investigated hyperfiltration using this definition and absolute GFR > 125 mL/min.
View Article and Find Full Text PDFDetermination of urine volume and glomerular filtration rate using d-serine and d-asparagine.
Nephrol Dial Transplant
November 2024
Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.
Article Synopsis
- The study explores the measurement of glomerular filtration rate (GFR), suggesting that the rare amino acids d-serine and d-asparagine can provide a more accurate assessment than traditional urine collection methods.
- A cross-sectional analysis involving 209 kidney transplant donors and recipients utilized urine levels of these amino acids to establish an equation for estimating urine volume (eUV), which helped correct GFR measurements.
- Results showed that d-serine and d-asparagine clearances had less bias compared to creatinine, highlighting their potential for improving GFR estimations and urine volume assessments.
Euphorbium compositum SN improves the innate defenses of the airway mucosal barrier network during rhinovirus infection.
Respir Res
November 2024
Center for Inflammation and Lung Research, Lewis Katz Medical School, Temple University, Philadelphia, PA, 19140, USA.
Background: Rhinoviruses (RV) are the major cause of common colds in healthy individuals and are associated with acute exacerbations in patients with chronic lung diseases. Yet, no vaccines or effective treatment against RV are available. This study investigated the effect of Euphorbium compositum SN (ECSN6), a multicomponent, multitarget medication made from natural ingredients, on the mucosal barrier network during RV infection.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!