Aim: To investigate the expression of inflammatory cytokines in patients with sepsis by cytokine antibody chips.
Methods: To screen the protein biomarker for rapidly diagnosing sepsis, 79 cytokines in 9 cases of patients with sepsis and 4 cases of healthy control were measured using cytokine antibody chip. Analyse the signaling values of these 79 cytokines using SAM (significance analysis of microarray, SAM) software.
Results: By SAM analysis: insulin like growth factor binding protein-1 (IGFBP-1), epidermal growth factor (HGF), osteopotin, insulin like growth factor binding protein-4 (IGFBP-4), interferon inducible protein-10 (IP-10) and B-lymphocyte chemoattractant (BLC) were identified to be highly expressed in the sepsis while platelet-derived growth factor-BB (PDGF-BB), brain-derived neurotrophic (BDNF), macrophage inflammatory protein-1β (MIP-1β), interleukin-8 (IL-8), epidermal growth factor (EGF) and interleukin-1β(IL-1β)lowly expressed. Cluster analysis of significantly expressed cytokines showed that the sepsis and the control formed distinctly separate groups.
Conclusion: Antibody chips demonstrate a significant change in sepsis patients, screening the protein biomarker for rapidly diagnosing sepsis is feasible.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Distinct peripheral pro-inflammatory profile associated with tuberous sclerosis complex and epilepsy.
Epilepsia
January 2025
Department of Neurosciences, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Objective: Tuberous sclerosis complex (TSC) is a monogenetic disorder associated with sustained mechanistic target of rapamycin (mTOR) activation, leading to heterogeneous clinical manifestations. Epilepsy and renal angiomyolipoma are the most important causes of morbidity in adult people with TSC (pwTSC). mTOR is a key player in inflammation, which in turn could influence TSC-related clinical manifestations.
View Article and Find Full Text PDFVaccinia growth factor-dependent modulation of the mTORC1-CAD axis upon nutrient restriction.
J Virol
January 2025
Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
The molecular mechanisms by which vaccinia virus (VACV), the prototypical member of the poxviridae family, reprograms host cell metabolism remain largely unexplored. Additionally, cells sense and respond to fluctuating nutrient availability, thereby modulating metabolic pathways to ensure cellular homeostasis. Understanding how VACV modulates metabolic pathways in response to nutrient signals is crucial for understanding viral replication mechanisms, with the potential for developing antiviral therapies.
View Article and Find Full Text PDFcolonization is not mediated by bile salts and utilizes Stickland fermentation of proline in an model.
mSphere
January 2025
Department of Food Science and Technology and Nebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Treatment with antibiotics is a major risk factor for infection, likely due to depletion of the gastrointestinal microbiota. Two microbiota-mediated mechanisms thought to limit colonization include the conversion of conjugated primary bile salts into secondary bile salts toxic to growth and competition between the microbiota and for limiting nutrients. Using a continuous flow model that simulates the nutrient conditions of the distal colon, we investigated how treatment with 6 clinically used antibiotics influenced susceptibility to infection in 12 different microbial communities cultivated from healthy individuals.
View Article and Find Full Text PDFAntagonisation of Prokineticin Receptor-2 Attenuates Preeclampsia Symptoms.
J Cell Mol Med
January 2025
Interdisciplinary Research Institute of Grenoble, IRIG-Biosanté, University Grenoble Alpes, INSERM, CEA, UMR 1292, Grenoble, France.
Preeclampsia (PE) is the most threatening pathology of human pregnancy. Placenta from PE patients releases harmful factors that contribute to the exacerbation of the disease. Among these factors is the prokineticin1 (PROK1) and its receptor, PROKR2 that we identified as a mediators of PE.
View Article and Find Full Text PDFLeaf Size Determines Damage- and Herbivore-Induced Volatile Emissions in Maize.
Plant Cell Environ
January 2025
Institute of Plant Sciences, University of Bern, Bern, Switzerland.
Stress-induced plant volatiles play an important role in mediating ecological interactions between plants and their environment. The timing and location of the inflicted damage is known to influence the quality and quantity of induced volatile emissions. However, how leaf characteristics and herbivore feeding behaviour interact to shape volatile emissions is not well understood.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!