Aim: To observe the change and the clinical significance of S100β protein level in cerebrospinal fluid and serum from the patients with cerebral hemorrhage (CH).
Methods: ELISA was used to detect the expression of S100β protein in CSF and serum from CH patients control with Inguinal Hernia or great saphenous varix patients. Meanwhile, rabbit CH model at 6 h, 12 h, 24 h, 48 h, 72 h and 96 h .
Results: The levels of CSF S100β protein at acute stage of CH patients increased significantly compared with those at recovery stage of CH patients and control group(P<0.01). The levels of S100β protein in CSF from CH patients increased significantly compared with those in serum (P<0.01).The levels of S100β protein in CSF of rabbit experimental group increased significantly compared with those of sham operation group at different time points(P<0.01).
Conclusion: The level of S100β protein in CSF from CH patients increases. It may be a biomarker as reflecting degree of pathogenetic and predicting outcome in the CH patients.
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