[Expressions of receptor tyrosine kinases mRNA and protein in carcinoma of bladder].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao

Department of Urology, PUMC Hospital, Beijing, China.

Published: August 2011

Objective: To detect the expressions of receptor tyrosine kinases (RTKs) mRNA and protein and to explore potentially promising tumor markers and conceivable drug target in bladder cancer.

Methods: The expressions of RTKs mRNA and protein in tissue from invasive urothelial carcinoma of the bladder were examined by real-time quantitative PCR array and cytokine antibody array, with normal bladder tissue as control. The Results were analyzed using bioinformatic approaches.

Results: The expressions of TGFA, STAB1, SERPINE1, ANGPT2, SPINK5, ANGPTL1, PROK1, MDK, CXCL9, GRN, RUNX1, VEGFA, and TGFB1 were obviously upregulated in bladder cancer tissue, while those of EDIL3, PTN, CCL2, PDGFD, FGF13, KITLG, FGF2, SERPINF1, and TNF were downregulated. ALK, Btk, EphB2, ErbB4, PDGFR-α, ROS, Tie-2, Tyk2, and VEGFR3 were over-expressed in bladder cancer, while FRK, Fyn, IGF-IR, Insulin R, Itk, JAK1, JAK3, and LCK were low-expressed.

Conclusion: Vascular endothelial growth factor/platelet-derived growth factor-targeted therapies may play an active role in treating carcinoma of bladder.

Download full-text PDF

Source
http://dx.doi.org/10.3881/j.issn.1000-503X.2011.04.009DOI Listing

Publication Analysis

Top Keywords

mrna protein
12
receptor tyrosine
8
tyrosine kinases
8
rtks mrna
8
carcinoma bladder
8
bladder cancer
8
bladder
6
[expressions receptor
4
kinases mrna
4
protein carcinoma
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!