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http://dx.doi.org/10.1002/anie.201103365 | DOI Listing |
Angew Chem Int Ed Engl
December 2024
Department of Chemistry, Biochemistry & Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland.
High-throughput combinatorial metal complex synthesis has emerged as a powerful tool for rapidly generating and screening diverse libraries of metal complexes, enabling accelerated discovery in fields such as catalysis, medicinal chemistry, and materials science. By systematically combining building blocks under mild and efficient conditions, researchers can explore broad chemical spaces, increasing the likelihood of identifying complexes with desired properties. This method streamlines hit identification and optimisation, especially when integrated with high-throughput screening and data-driven approaches like machine learning.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Institute of Bast Fiber Crops & Center of Southern Economic Crops, Chinese Academy of Agricultural Sciences, Key Laboratory of Biological and Processing for Bast Fiber Crops of Ministry of Agriculture and Rural Affairs, Engineering and Technology Center for Bast Fiber Crops of Hunan Province, Changsha 410205, China. Electronic address:
The inability to utilize pentose poses as a significant limitation to the production of cellulosic ethanol. To attain efficient raw material conversion and mitigate carbon dioxide emissions during cellulosic ethanol synthesis, a integrated approach focused on the co-processing of ethanol and succinic acid (SA) from peanut shells was proposed. The results demonstrated that the GVL system, containing 30 % water and catalyzed by dilute sulfuric acid, exhibited remarkable efficiency in pretreatment, boosting glucose yield sixfold relative to the untreated raw material.
View Article and Find Full Text PDFBioengineering (Basel)
November 2024
Xiangya International Academy of Translational Medicine, Central South University, Changsha 410013, China.
Int J Biol Macromol
January 2025
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Laboratory on Food Science and Safety, Jiangnan University, Wuxi, Jiangsu 214122, China.
Int J Biol Macromol
December 2024
College of Life Sciences, Wuhan University, Wuhan 430072, China. Electronic address:
The 3-ketosteroid-Δ-dehydrogenase5 (KsdD) from Arthrobacter simplex converts cortisone acetate to prednisone acetate, an important step in steroid catabolism. To achieve sustainable and efficient enzyme production, we employed computer-aided screening, structural analysis, and combinatorial experiments to identify engineered KsdD variants (M1 and M3) with dual advantages of stability and active sites. M1 had a 8.
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