AI Article Synopsis
- The proper development of the vertebrate central nervous system (CNS) depends on generating specific types of neurons and glial cells at the appropriate times and locations.
- Tcf3, a protein in the Lef/Tcf family, plays a key role in preventing spinal cord precursor cells from prematurely becoming oligodendroglial cells, as demonstrated by a transgenic zebrafish model.
- This research indicates that Tcf3's influence on oligodendroglial fate specification occurs independently of the canonical Wnt signaling pathway, highlighting a new aspect of Tcf3’s function in spinal cord development.
Article Abstract
The generation of various subtypes of neurons and glial cells at the right time and place is crucial for the proper development of the vertebrate CNS. Although the mechanisms and factors for the regulation of neuronal diversity in the CNS have been well studied, the mechanisms regulating the sequential production of neuronal and glial cells from neural precursors remain poorly understood. This study shows that Tcf3, a member of the Lef/Tcf family of proteins, is required to inhibit the premature oligodendroglial fate specification of spinal cord precursors using the transgenic zebrafish, which expresses a dominant repressor form of Tcf3 under the control of a heat-shock inducible promoter. In addition, the data revealed that Tcf3 function in oligodendroglial fate specification is mediated independently of canonical Wnt signaling. Altogether, these results show a novel function for Tcf3 in regulating the timing of oligodendroglial fate specification in the spinal cord.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887649 | PMC |
| http://dx.doi.org/10.1007/s10059-011-0152-1 | DOI Listing |
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