AI Article Synopsis
- - Cryptosporidium parvum is a parasite that causes cryptosporidiosis, a diarrheal illness transmitted through contaminated water via the fecal-oral route.
- - Triosephosphate isomerase is an essential enzyme in glycolysis that helps convert dihydroxyacetone phosphate into glyceraldehyde 3-phosphate, crucial for maximizing ATP production.
- - The paper discusses a crystal structure of triosephosphate isomerase from C. parvum at 1.55 Å resolution, revealing an unidentified electron density at its active site.
Article Abstract
Cryptosporidium parvum is one of several Cryptosporidium spp. that cause the parasitic infection cryptosporidiosis. Cryptosporidiosis is a diarrheal infection that is spread via the fecal-oral route and is commonly caused by contaminated drinking water. Triosephosphate isomerase is an enzyme that is ubiquitous to all organisms that perform glycolysis. Triosephosphate isomerase catalyzes the formation of glyceraldehyde 3-phosphate from dihydroxyacetone phosphate, which is a critical step to ensure the maximum ATP production per glucose molecule. In this paper, the 1.55 Å resolution crystal structure of the open-loop form of triosephosphate isomerase from C. parvum Iowa II is presented. An unidentified electron density was found in the active site.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169408 | PMC |
| http://dx.doi.org/10.1107/S1744309111019178 | DOI Listing |
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