Aging is associated with cognitive deterioration. A recent study showed two polymorphisms (rs505058 in LMNA and rs11622883 near a SERPINA13 gene), identified in a genome-wide association study of late-onset Alzheimer's disease, to be associated with cognitive function (Mini Mental State Examination) in a UK elderly population. This study replicated these findings in Chinese elderly males without dementia. A total of 358 elderly subjects were assessed by the Cognitive Abilities Screening Instruments (CASI) and the Wechsler Digit Span Task tests. Analysis of covariance was used to compare cognitive scores among genotypic groups, with age and total education years as covariates. The two polymorphisms were not associated with the global cognitive function or specific cognitive domains in the elderly without dementia. Our data argue against that these two polymorphisms may affect cognitive function in the elderly.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neulet.2011.08.051 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The development of preterm infants from low socio-economic status families: The combined effects of melatonin, autonomic nervous system maturation and psychosocial factors (ProMote): A study protocol.
PLoS One
January 2025
Department of Neonatology/Neonatal Intensive Care Unit, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Crete, Greece.
Preterm births constitute a major public health issue and a chronic, cross-generational condition globally. Psychological and biological factors interact in a way that women from low socio-economic status (SES) are disproportionally affected by preterm delivery and at increased risk for the development of perinatal mental health problems. Low SES constitutes one of the most evident contributors to poor neurodevelopment of preterm infants.
View Article and Find Full Text PDFThe Effects of Trait Anger on Proactive and Reactive Online Aggression: The Mediating Role of Hostile Attribution Bias and the Moderating Role of Self-Control.
Psychol Rep
January 2025
School of Management, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Individuals' involvement in reactive and proactive online aggression has garnered widespread concern from various societal sectors, marking it as a critical indicator of individual social development. The influencing factors that might exist for both reactive and proactive online aggression have been little explored. Understanding these could help us develop more effective intervention strategies, targeting individuals who exhibit both types of aggression.
View Article and Find Full Text PDFMuscle relaxation enhances motor imagery capacity in people with anxiety: A randomized clinical trial.
PLoS One
January 2025
Department of Nursing and Physiotherapy, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Spain.
Background: Motor imagery is the mental representation of a movement without physical execution. When motor imagery is performed to enhance motor learning and performance, participants must reach a temporal congruence between the imagined and actual movement execution. Identifying factors that can influence this capacity could enhance the effectiveness of motor imagery programs.
View Article and Find Full Text PDFHow breakthroughs happen: Unearthing the boundary conditions of eco-friendly deliberate practice and eco-innovation performance.
PLoS One
January 2025
National Business School, The University of Faisalabad, Faisalabad, Pakistan.
Surprisingly innovation process based on deliberate practice has rarely been unearthed that might explore the boundary conditions of the eco-friendly deliberate practice and eco-innovation performance relationship. Anchored on the organizational support theory and the social cognitive, the current study seeks to investigate the impacts of perceived organizational support (POS) and developmental leadership (DL) on eco-innovation performance (EP) through the mediating role of eco-friendly deliberate practice (EDP). In addition, the study explores the boundary effects of employee resilience (ER) on the relationship between EDP and EP.
View Article and Find Full Text PDFEffect of pig breeding scale on manure resource utilization-The moderating effect based on technology cognition.
PLoS One
January 2025
School of Economics and Management, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
The utilization of manure resources is an important measure to promote the development of agricultural green low-carbon cycle and solve the challenges associated with the current large-scale development of the livestock and poultry breeding industry. Based on the survey data of pig farmers in Qingdao, Shandong Province, China, this paper constructs a theoretical analysis framework of pig breeding scale and technical cognition on the utilization behavior of livestock and poultry manure resources of pig farmers. The binary Logit model and the moderating effect model are used to deeply explore the scale effect of breeding scale on the utilization behavior of pig farmers' manure resources, and the moderating effect of technical cognition on the influence of breeding scale on the utilization behavior of manure resources.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!