Reduced corticosteroid use in adult patients with primary immune thrombocytopenia receiving romiplostim.

Marc Michel Peter A W te Boekhorst Ann Janssens Ingrid Pabinger-Fasching Miguel A Sanz Kun Nie Georg Kreuzbauer

Hematology

CHU Henri Mondor AP-HP, Université Paris, 51 Av du Mal de Lattre de Tassigny, Créteil, France.

Published: September 2011

Adult patients with primary immune thrombocytopenia requiring first-line treatment typically receive corticosteroids, which are associated with low response rates and many potential side effects. In a retrospective analysis of two 6-month, placebo-controlled, phase III trials, corticosteroid use decreased from 30 to 26% among patients treated with the novel thrombopoietin-mimetic romiplostim (n = 83) and remained above 30% for placebo-treated patients (n = 42). Moreover, compared to placebo, patients were spared 7 weeks of corticosteroid treatment for every 100 weeks of romiplostim treatment. Thereafter, corticosteroid use continued to decrease significantly, from 35 to 20%, in patients treated with romiplostim for up to 3 years in an open-label extension study (n = 101), and patients were spared a further 8 weeks of corticosteroid treatment for each additional 100 weeks of romiplostim treatment. Such reductions in corticosteroids may improve health-related quality of life in patients with primary immune thrombocytopenia.</p><table class="table table-bordered table-striped downloadTable" > <thead > <tr> <th ><h3>Download full-text PDF</h3></th> <th >Source</th> </tr></thead> <tbody><tr><td><i class='icon-doc'></i><a href='http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178451' rel='nofollow' target='_blank' onClick='ga("send", "event", "fulltextclick_PMC", "click", "article");' style='text-decoration:underline;' class='clickTrack' data-ref='fulltext-21902890-n'>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178451</a></td><td>PMC</td></tr><tr><td><i class='icon-doc'></i><a href='http://dx.doi.org/10.1179/102453311X13025568942005' rel='nofollow' target='_blank' onClick='ga("send", "event", "fulltextclick_DOI Listing", "click", "article");' style='text-decoration:underline;' class='clickTrack' data-ref='fulltext-21902890-n' 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onClick='ga("send", "event", "linkedin", "share", "article");' title="" class="in socialShare" id="in-a-21902890"><i class="icon-linkedin"></i></a></div><div class="row" ><div class="pubfacts-artical-heading right-head" style="margin-bottom:30px; margin-top:30px; " > <h2 style="padding-bottom:5px">Publication Analysis</h2> </div> <div class="col-md-12"> <h4>Top Keywords</h4> <div class="review-list d-flex align-items-center mb10"> <div class="list-number">patients primary</div> <div class="progress"> <div class="progress-bar" style="width: 100%;" role="progressbar" aria-valuenow="100" aria-valuemin="0" aria-valuemax="100"></div> </div> <div class="value text-end">12</div> </div> <div class="review-list d-flex align-items-center mb10"> <div class="list-number">primary immune</div> <div class="progress"> <div class="progress-bar" style="width: 100%;" role="progressbar" aria-valuenow="100" aria-valuemin="0" aria-valuemax="100"></div> </div> <div class="value text-end">12</div> </div> <div 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