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Total synthesis of pacidamycin D by Cu(I)-catalyzed oxy enamide formation. | LitMetric

AI Article Synopsis

  • - The text details the first complete synthesis of pacidamycin D, a promising antibacterial agent targeting P. aeruginosa.
  • - The synthesis involves a highly efficient and stereocontrolled method to create Z-oxyvinyl iodide.
  • - It also includes a copper-catalyzed cross-coupling reaction with a tetrapeptide carboxamide to achieve the final product.

Article Abstract

The first total synthesis of pacidamycin D, which is expected to be a good candidate as an antibacterial agent against P. aeruginosa, is described. The key elements of our approach feature an efficient and stereocontrolled construction of the Z-oxyvinyl iodide and copper-catalyzed cross-coupling with the tetrapeptide carboxamide.

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Source
http://dx.doi.org/10.1021/ol202124bDOI Listing

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