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Impact of molecular classification on prognosis in children and adolescents with spinal ependymoma: Results from the HIT-MED database.
Neurooncol Adv
October 2024
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Background: Ependymomas of the spinal cord are rare among children and adolescents, and the individual risk of disease progression is difficult to predict. This study aims to evaluate the prognostic impact of molecular typing on pediatric spinal cord ependymomas.
Methods: Eighty-three patients with spinal ependymomas ≤22 years registered in the HIT-MED database (German brain tumor registry for children, adolescents, and adults with medulloblastoma, ependymoma, pineoblastoma, and CNS-primitive neuroectodermal tumors) between 1992 and 2022 were included.
Evaluation of pediatric spinal ependymomas: A 25-year retrospective observational study.
Medicine (Baltimore)
December 2024
Department of Neurosurgery, Hacettepe University Faculty of Medicine, Ankara, Turkey.
This study aims to evaluate the clinical and radiological features, histopathological characteristics, treatment modalities, and their effectiveness, as well as long-term follow-up results of pediatric spinal ependymomas treated at a single institution. In this retrospective study, medical records of 14 pediatric patients (3 females and 11 males) who were surgically treated for spinal ependymoma in our institution between 1995 and 2020 were reviewed. Data regarding age, gender, presenting symptoms and signs, radiological findings, postoperative status, extent of resection, histopathological grading, recurrence, tumor growth, seeding, and adjuvant treatment were collected and analyzed.
View Article and Find Full Text PDFEpidemiological characteristics of myxopapillary ependymoma and factors affecting overall survival: a SEER-based analysis.
Transl Cancer Res
November 2024
Department of Neurosurgery, Jiangmen Central Hospital, Jiangmen, China.
Article Synopsis
- Myxopapillary ependymoma (MPE) is a rare tumor, and the study aimed to investigate its epidemiological features and overall survival factors using data from the SEER database (2004-2015).
- The analysis involved 1,026 MPE cases, highlighting that incidence rates showed no significant trends over time, with higher rates in specific age groups and disparities based on race and gender.
- Key factors influencing overall survival included older age, being widowed, lack of surgery, and the impact of radiotherapy, emphasizing the need for further research to better understand these relationships.
Pediatric skull base tumors: Clinical features and surgical outcomes; a single center retrospective study with a review of literature.
Brain Spine
November 2024
Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
Article Synopsis
- Pediatric intracranial tumors at the skull base are rare, challenging to treat due to complex anatomy, and lack substantial clinical evidence, prompting a study on surgical approaches and outcomes.
- The study involved 12 children under 18 who underwent skull base surgery from 2017 to 2023, analyzing demographics, tumor details, surgical methods, and survival rates.
- Results indicated a predominance of female patients, varying tumor locations and types, with 58.3% achieving gross or near-total resection; however, 33.3% of patients died from tumor progression within an average of 15 months.
Pediatric Renal Cell Carcinoma (pRCC) Subpopulation Environmental Differentials in Survival Disadvantage of Black/African American Children in the United States: Large-Cohort Evidence.
Cancers (Basel)
November 2024
Global Health Equity Foundation, Bear, DE 19701, USA.
Article Synopsis
- Pediatric renal cell carcinoma (pRCC) is a rare, aggressive cancer in children with lower survival rates compared to other pediatric cancers, influenced by factors like sex, race, ethnicity, age, and socio-economic status.
- A retrospective study analyzed 174 pRCC cases from 1973 to 2015 to understand survival rates, identifying significant disparities, such as black/AA children being nearly three times more likely to die from the disease than white children.
- The study highlights the need for further research into socio-economic and demographic factors affecting pRCC outcomes, as well as exploring insufficiently studied determinants like area of residence.
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