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http://dx.doi.org/10.1016/j.foot.2011.08.003DOI Listing

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Article Synopsis
  • * This review examines existing research on the prognostic implications of HNSCC’s histopathologic subtypes, noting a lack of studies focusing specifically on treatment outcomes for each subtype.
  • * The review highlights that some subtypes, like verrucous and cuniculatum, have better prognoses compared to others like basaloid and spindle cell, and it emphasizes the need for more molecular research to develop targeted therapies and improve prognostic assessments.
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Carcinoma cuniculatum is a variant of squamous cell carcinoma, characterized by a slow growth with progressive crypt-like invasion of deep tissue. This tumor is frequently misdiagnosed as a benign skin lesion both clinically and histopathologically. The final diagnosis is often delayed as it requires a large sample biopsy.

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Background: Oral carcinoma cuniculatum (CC) is a rare variant of squamous cell carcinoma. It exhibits a locally aggressive behaviour, and its histopathology poses a diagnostic challenge, as it can be mistaken for other conditions. We present five cases of oral CC treated at our institution and conduct a comprehensive review of the current literature.

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Carcinoma cuniculatum (CC) is a rare and distinct clinicopathological variant of well-differentiated squamous cell carcinoma. It is a rare and slow-growing tumor with a peculiar infiltrative growth pattern resembling rabbit burrows (cuniculi). It usually occurs over the plantar aspect of the foot but can also occur at other sites like the oral cavity and genitals.

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