Blister beetle dermatosis is a distinctive vesiculobullous eruption that occurs after contact with three major groups of beetles (Order: Coleoptera). It is caused by a vesicant chemical contained in the body fluids of the beetles. The smallest and least known family is the Oedemeridae. Although there are few references in the medical literature, blister beetle dermatosis caused by oedemerids may be more common and widespread than currently recognized. The best known family is the Meloidae with numerous species worldwide causing blistering. The vesicant chemical in both Oedemeridae and Meloidae is cantharidin. The third group of blister beetles includes species of the genus Paederus (Family: Staphylinidae). The clinicopathologic picture differs because this genus contains a different vesicant agent, pederin. The clinicopathologic features of oedemerid blister beetle dermatosis are described. The world medical and relevant entomologic literature is reviewed.
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Paederus dermatitis, also known as dermatitis linearis, is an acute cutaneous condition caused by contact with the potent vesicant toxin paederin, produced by endosymbiotic Pseudomonas-like bacteria within Paederus spp. beetles. Paederin is a protein synthesis inhibitor that halts cell division, leading to vesiculation and necrotic breakdown of the epidermis.
View Article and Find Full Text PDFArticle Synopsis
- - Paederus contact dermatitis is a skin condition caused by beetles from the Paederus genus, which release a harmful toxin called paederin, commonly found in hot climates and during rainy seasons.
- - Symptoms include red patches with blisters on the skin, often accompanied by burning and itching, as demonstrated by a case of a 28-year-old male who developed lesions after vacationing in Ecuador.
- - Treatment involves washing the affected area, using topical steroids, and antihistamines; in the reported case, the patient improved significantly after 8 days, although some dark spots remained after the lesions healed.
The emerging role of FAM46C as a biomarker and therapeutic target in gastric adenocarcinoma.
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- Gastric adenocarcinoma (GCa) has a high fatality rate in Europe and North America, largely due to late-stage diagnoses, despite advancements in treatment options.
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