A general method for synthesis of GPI anchors illustrated by the total synthesis of the low-molecular-weight antigen from Toxoplasma gondii.

Angew Chem Int Ed Engl

Department of Biomolecular Systems, Max Planck Institut of Colloids and Interfaces, Potsdam, Germany.

Published: October 2011

Building blocks: a new, general synthetic strategy, which allows the construction of branched glycosylphosphatidylinositols (GPIs), enables the synthesis of parasitic glycolipid 1 from Toxoplasma gondii. In addition, the structure is further confirmed by recognition of monoclonal antibodies.

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http://dx.doi.org/10.1002/anie.201103483DOI Listing

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