Isolation and semisynthetic modification of the fungal metabolite chaetocin gave access to a desulfurized analogue of this natural product. Detailed chiroptical studies, comparing experimentally obtained optical rotation values, electronic circular dichroism spectra, and vibrational circular dichroism spectra to computationally simulated ones, reveal the desulfurization of chaetocin to unambiguously proceed with retention of configuration. Consideration of the plausible mechanisms for this process highlighted inconsistencies in the stereochemical assignment of related molecules in the literature. This in turn allowed the stereochemical reassignment of the natural product analogue dethiodehydrogliotoxin.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/chem.201101129 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of COVID-19 vaccination on hospitalization, hospital utilization and expenditure for COVID-19: A retrospective cohort analysis of a South African private health insured population.
PLoS One
January 2025
Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa.
This study quantifies the impact of COVID-19 vaccination on hospitalization for COVID-19 infection in a South African private health insurance population. This retrospective cohort study is based on the analysis of demographic and claims records for 550,332 individuals belonging to two health insurance funds between 1 March 2020 and 31 December 2022. A Cox Proportional Hazards model was used to estimate the impact of vaccination (non-vaccinated, partly vaccinated, fully vaccinated) on COVID-19 hospitalization risk; and zero-inflated negative binomial models were used to estimate the impact of vaccination on hospital utilization and hospital expenditure for COVID-19 infection, with adjustments for age, sex, comorbidities and province of residence.
View Article and Find Full Text PDFEffects of Cinnamomum zeylanicum (Ceylon cinnamon) extract on lipid profile, glucose levels and its safety in adults: A randomized, double-blind, controlled trial.
PLoS One
January 2025
Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Background: Cinnamon has been studied as a possible way to control blood glucose and serum cholesterol levels. However, there are no well-conducted randomized controlled trials that can accurately measure the lipid and glucose-lowering effects of Cinnamomum zeylanicum (C. zeylanicum) extract.
View Article and Find Full Text PDFCombating trade in illegal wood and forest products with machine learning.
PLoS One
January 2025
Department of Computer Science, Virginia Tech, Arlington, VA, United States of America.
Trade in wood and forest products spans the global supply chain. Illegal logging and associated trade in forest products present a persistent threat to vulnerable ecosystems and communities. Illegal timber trade has been linked to violations of tax and conservation laws, as well as broader transnational crimes.
View Article and Find Full Text PDFThe green response of financial inclusion, infrastructure development and renewable energy to the environmental sustainability: A newly evidence from OECD economies.
PLoS One
January 2025
Schools of Mathematics, International Islamic University, Islamabad, Pakistan.
Recently, economic environmental degradation is being considered a leading chellenge in forefront of policy analysts. Thus, the present study introduces core environmental determinants such as infrastructure development, finacail inclusion, gross domestic product, population, and renewable energy consumption. Financial inclusion (FI) is crucial for attaining a environment.
View Article and Find Full Text PDFDevelopment and nutritional evaluation of pomegranate peel enriched bars.
PLoS One
January 2025
Department of Food Science and Nutrition, Ethiopian Institute of Agricultural Research, Shashemene, Ethiopia.
Pomegranate peel powder is used as a functional ingredient in the development of nutritional bars. Pomegranate (Punica granatum) is well known fruit belongs to punicaceae family having multiple health benefits, not only limited to its edible parts but also in its non-edible parts mostly the peel. Fruit wastes are rich source of nutrients, and can be used for the development of functional food products.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!