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| http://dx.doi.org/10.4103/0976-500X.83298 | DOI Listing |
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Enhanced Killing of Methicillin-Resistant Staphylococcus aureus with Ceftaroline or Vancomycin in Combination with Carbapenems.
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Department of Pediatrics, University of California Irvine School of Medicine, Irvine, CA 92697, USA.
Background: Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with high rates of treatment failure, even when antibiotics showing in vitro susceptibility are used. Early optimization of therapy is crucial to reduce morbidity and mortality. Building on our previous research on carbapenem therapy for methicillin-susceptible S.
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Article Synopsis
- The research investigated the link between specific genes and biofilm formation in MRSA strains from skin and soft tissue infections, finding that certain genes were associated with stronger biofilm production.
- Out of 134 isolates tested, vancomycin was effective in 98.5% of cases, with very few showing resistance, while ceftaroline showed no resistance, suggesting it could be a viable alternative for treating resistant infections.
- The study found that the presence of certain genes correlated with varying levels of biofilm production, highlighting the need for further research on treatment options for MRSA-related infections amidst growing resistance concerns.
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