AI Article Synopsis
- The study aims to compare the effectiveness of buffered pantoprazole tablets to plain pantoprazole in preventing ulcers in rats with pyloric ligation.
- The experiment involved measuring gastric content volume, pH, acidity levels, and ulcer lesions, along with analyzing pantoprazole concentration using HPLC.
- Results indicated that buffered pantoprazole maintained a higher gastric pH for longer periods and provided better absorption in the gastric content and tissue, demonstrating its superior bioavailability over plain pantoprazole.
Article Abstract
Objective: To compare the anti-ulcer activity of buffered pantoprazole tablet against plain pantoprazole in pyloric ligated rats.
Materials And Methods: In vivo pyloric ligated ulcerogenesis model was used to assess the effect of buffered pantoprazole on the volume of the gastric content, pH, total and free acidity, and ulcerogenic lesion. Pantoprazole level in gastric content and concurrently in stomach tissue was assessed by High Performance Liquid Chromatography (HPLC) analysis.
Results: Buffered tablet effectively increases the pH of the gastric content above 4 up to 6 h (P<0.001) protecting pantoprazole from acid degradation resulting in high concentration in the gastric content and stomach tissue.
Conclusions: This study substantiates better, faster and prolonged bioavailability of pantoprazole-buffered tablet compared to plain pantoprazole.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157128 | PMC |
| http://dx.doi.org/10.4103/0976-500X.83283 | DOI Listing |
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