Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1331/JAPhA.2011.11540 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of Phosphodiesterase 4 Inhibition on the Operational Efficacy, Response Maxima, and Kinetics of Indacaterol-Induced Gene Expression Changes in BEAS-2B Airway Epithelial Cells: A Global Transcriptomic Analysis.
Mol Pharmacol
July 2019
Departments of Physiology and Pharmacology (R.J., D.Y., O.H., T.J., M.A.G.) and Cell Biology and Anatomy (M.M.M., R.N.), Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
The effects of phosphodiesterase (PDE) 4 inhibitors on gene expression changes in BEAS-2B human airway epithelial cells are reported and discussed in relation to the mechanism(s) of action of roflumilast in chronic obstructive pulmonary disease (COPD). Microarray-based gene expression profiling failed to identify mRNA transcripts that were differentially regulated by the PDE4 inhibitor 6-[3-(dimethylcarbamoyl)benzenesulphonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide (GSK 256066) after 1, 2, 6, or 18 hours of exposure. However, real-time polymerase chain reaction analysis revealed that GSK 256066 was a weak stimulus, and the negative microarray results reflected low statistical power due to small sample sizes.
View Article and Find Full Text PDFMini Review: Chronic obstructive pulmonary disease, its new drug treatments and strategies: A review.
Pak J Pharm Sci
May 2018
Department of Pathology, University of Agriculture, Faisalabad, Pakistan.
COPD is a complicated disease. Current available treatments are just for symptomatic relief and they cannot reverse the damages to lungs tissues due to alveolar destruction in COPD. Research is being conducted to evaluate new treatments and strategies to find specific treatments to minimize the symptoms of COPD.
View Article and Find Full Text PDFCOPD is a serious pulmonary disease with rising global socioeconomic impact. From the perspective of the Czech Republic COPD was responsible for 21 000 acute hospitalizations and 3 500 deaths, mortality reaches 33/100 000 in 2015. Early stages of disease may be associated with a significant reduction of exercise capacity and the reduction of activities of daily living.
View Article and Find Full Text PDFChronic obstructive pulmonary disease: Useful medications for patients with recurrent symptoms.
Prescrire Int
November 2016
Chronic obstructive pulmonary disease (COPD) is a respiratory disorder characterised by largely irreversible changes in air flow due to irritants such as tobacco smoke. Patients with COPD experience acute exacerbations. Severe disease may progress to chronic respiratory failure.
View Article and Find Full Text PDFRespiratory medications.
Nursing
January 2016
At Rutgers University Ernest Mario School of Pharmacy in Piscataway, N.J., Mary B. Bridgeman is a clinical associate professor. Kavitha S. Dalal is a critical care clinical pharmacist at Virtua in Marlton, N.J.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!