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Sex differences in the association between hypertension, cerebral small vessel disease and cognitive decline: a narrative review.
J Hypertens
March 2025
Department of Medicine, Faculty of Medicine and Health Sciences, McGill University Health Centre.
The objective of this study was to review how cerebral small vessel disease (CSVD) is associated with hypertension and cognitive decline, specifically regarding sex differences in this association. Strong evidence supports the associations between hypertension and cognitive decline, hypertension and CSVD, as well as CSVD and cognitive decline in both women and men. Sex-stratified analyses show that compared to men, hypertension leads to worse cognitive decline in women likely due to its stronger association with CSVD in women.
View Article and Find Full Text PDFVenous leg ulcers: A review of clinical variability and differential diagnosis.
Vasc Med
March 2025
Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Venous hypertension due to anatomical venous insufficiency (superficial or deep venous valvular reflux and venous obstruction) and/or functional venous insufficiency (calf dysfunction, dependent edema, lymphatic dysfunction, elevated central venous pressures, etc.) leads to chronic venous insufficiency (CVI) and its sequelae. The most severe clinical manifestation of CVI is venous leg ulcer (VLU), which leads to substantial morbidity and disability.
View Article and Find Full Text PDFPhytochemical, In Silico, In Vitro, and In Vivo Research on Piptadeniastrum africanum (Fabaceae) Unveiling Anti-Stereotypic, Anxiolytic, and Analgesic Effects in a Sodium Valproate-Induced Autistic Disorders Model.
Brain Behav
March 2025
Department of Animal Biology and Physiology, Laboratory of Animal Physiology, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.
Objective: Individuals with autistic spectrum disorders (ASD) primarily exhibit deficits in communication and social interaction, along with repetitive behaviors and restricted interests. This disorder is often associated with anxiety, nociceptive disorders, and pain. While medical treatment generally focuses on treating the symptoms rather than addressing the underlying causes, traditional medicine is sometimes used as an alternative.
View Article and Find Full Text PDFResponse to letter regarding "A pilot trial exploring the use of music in the emergency department and its association with delirium and other clinical outcomes".
Emerg Med Australas
April 2025
UNSW Sydney, Sydney, New South Wales, Australia.
Dried blood spot sampling offers a scalable strategy to close diagnostic gaps and improve global surveillance for cardiovascular-kidney-metabolic syndrome. However, assay performance and the extent of validity vary widely between biomarkers used in cardiovascular-kidney-metabolic health assessment under different settings and have not been well described. To fill this gap, we conducted a systematic search of the literature and a narrative synthesis through April 2024 and included reports with laboratory or field validation measuring biomarkers that can be used in cardiovascular-kidney-metabolic health assessment.
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