Cognitive deficit is a core feature of schizophrenia mostly grasping memory, psychomotor processing, attention, thinking, and executive functioning and is already present in the prodromal phase of the illness and is detected at the onset. Recent studies have been focused on the differentiation of cognitive functioning in relation to the diagnostic categories, which reveal cognitive heterogeneity in schizophrenia and schizophrenia spectrum disorders. The study demonstrated that along with changes in the clinical state, specifically, with reduction of psychopathological symptoms, patients with schizoaffective disorders show more positive dynamics with better chances to back up while in schizophrenia the cognitive dysfunction is more defined and less prone to improvement.
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Alzheimers Dement
December 2024
Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, 2007, NSW, Australia.
Background: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the impairment of cognitive development and disruption of neurocognitive function. This neuropathological condition is marked by neurodegeneration, loss of neural tissue, and the formation of neurofibrillary tangles and Aβ plaques. Various studies reported the utilization of phytoconstituents like fisetin, quercetin, berberine, and xanthohumol for the treatment of AD.
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December 2024
Kyunghee University Hospital at Gangdong, Seoul, Korea, Republic of (South).
Background: Recent preclinical studies have revealed a significant reduction in amyloid-β plaques and pro-inflammatory cytokines in Alzheimer's disease (AD) mouse models following low-dose radiation therapy (LDRT). This phase II, multicenter, prospective, single-blinded, randomized controlled trial (NCT05635968, funding from Korea Hydro & Nuclear Power: Grant No. A21IP11) aims to investigate the efficacy and safety of whole-brain LDRT in patients with AD.
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December 2024
Newcastle University, Newcastle, Newcastle Upon Tyne, United Kingdom.
Background: HIV-associated neurocognitive disorders (HAND) are prevalent complications of ageing with treated HIV, disproportionally affecting sub-Saharan Africa. Causal HAND treatments are lacking worldwide; therefore, reversible factors are important to explore. Sleep duration and quality are frequently associated with risk of cognitive impairments.
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December 2024
Nova Southeastern Dr. Kiran C. Patel College of Osteopathic Medicine - TBR, Clearwater, FL, USA.
Background: Research heavily suggests that brain-derived neurotrophic factor (BDNF), vital for neuronal growth and plasticity, and cholecystokinin (CCK), a satiety hormone that regulates BDNF levels, are altered in Alzheimer's Disease pathophysiology. Factors such as dysbiosis of gut microbiota and poor food habits may affect CCK and BDNF release and brain function. The objective is to evaluate the effects of dietary habits, gut microbiota, and exercise on BDNF and CCK release in Alzheimer's Disease patients.
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December 2024
Jeonbuk Provincial Dementia Center, Jeonju, Korea, Republic of (South).
Background: Combined cognitive training and physical activity has been known to improve brain function. The purpose of this study is to investigate whether combined intervention affects the improvement of cognitive function in the community-dwelling elderly, and to determine if it improves physical function, such as motor speed and balance.
Method: The study was conducted among community-dwelling elderly aged 65 years.
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