An outstanding challenge in neuroscience is to develop theoretically grounded and practically applicable quantitative measures that are sensitive to conscious level. Such measures should be high for vivid alert conscious wakefulness, and low for unconscious states such as dreamless sleep, coma and general anaesthesia. Here, we describe recent progress in the development of measures of dynamical complexity, in particular causal density and integrated information. These and similar measures capture in different ways the extent to which a system's dynamics are simultaneously differentiated and integrated. Because conscious scenes are distinguished by the same dynamical features, these measures are therefore good candidates for reflecting conscious level. After reviewing the theoretical background, we present new simulation results demonstrating similarities and differences between the measures, and we discuss remaining challenges in the practical application of the measures to empirically obtained data.
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http://dx.doi.org/10.1098/rsta.2011.0079 | DOI Listing |
BMJ Open
January 2025
Department of Anaesthesiology, China-Japan Friendship Hospital, Beijing, Beijing, China.
Introduction: Nociception monitoring has recently gained recognition as a valuable tool for guiding intraoperative opioid administration. Several nociception monitors, including the Surgical Pleth Index, the Index of Consciousness (IoC) and the Nociception Level, have been introduced for managing intraoperative analgesia. While these technologies show promise in initial applications, the effectiveness of IoC2 in guiding pain management during anaesthesia, particularly in elderly patients who require precise opioid use, remains unclear.
View Article and Find Full Text PDFCureus
December 2024
Emergency and Critical Care Medicine, Iizuka City Hospital, Iizuka, JPN.
Urinary tract infections (UTIs) caused by urease-producing bacteria are known to cause hyperammonemia; however, non-urease-producing bacteria can also cause it. This report describes a case of an 87-year-old woman who developed hyperammonemia and impaired consciousness resulting from a UTI caused by the non-urease-producing bacterium, (). On admission, the patient presented with urinary retention, hyperammonemia (281 μg/dL), and alkaline urine (pH 8.
View Article and Find Full Text PDFJ Community Hosp Intern Med Perspect
November 2024
Department of Internal Medicine, Division of Nephrology, Nassau University Medical Center, East Meadow, NY, USA.
Background: Impaired consciousness is associated with complications and mortality in COVID-19 patients. We study factors associated with impaired consciousness as measured by the Glasgow Coma Scale (GCS) in COVID-19 patients.
Methods: This is a retrospective study of 604 patients with COVID-19 in the metropolitan New York City area.
J Wound Ostomy Continence Nurs
January 2025
Tianxiang Jiang, BS, RN, Intensive care unit, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Linhai, Zhejiang Province, China, School of Nursing, Dalian University, Dalian City, Liaoning Province, China.
Purpose: A meta-analysis was conducted to comprehensively identify risk factors of incontinence-associated dermatitis (IAD) in adults and provide evidence-based support for healthcare professionals to formulate IAD preventive interventions and bundled interventions.
Methods: Systematic review and meta-analysis of pooled findings.
Search Strategy: Two researchers independently searched databases PubMed, EBSCO, Cochrane Library, Embase, Medline, Web of Science and Scopus and 4 Chinese databases (CNKI, Wanfang Data, VIP and CBM) for relevant studies published from their inception to March 15, 2023.
Hum Brain Mapp
February 2025
Neuroscience and Neuroengineering Research Laboratory, Biomedical Engineering Department, School of Electrical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran.
Implicit motor learning involves the acquisition and consolidation of motor skills without conscious awareness, influenced by various factors. Punishment and reward have been identified as significant modulators during training, impacting skill acquisition differently. Additionally, the role of a second declarative task in offline consolidation has been explored, affecting both stabilization and enhancement processes during wake and sleep periods.
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