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| http://dx.doi.org/10.1186/cc10275 | DOI Listing |
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Background: Kirschner wire (K-wire) and intramedullary (IM) screw fixation are accepted techniques for treatment of unstable proximal phalanx fractures, but comparative reports are lacking. This study aimed to evaluate early clinical outcomes following treatment with K-wire or IM fixation.
Methods: A retrospective review of all proximal phalanx fractures treated surgically at a single center by multiple surgeons was performed from May 1, 2019 to March 1, 2024.
KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors.
J Transl Med
January 2025
Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Background: KRAS-G12C inhibitors mark a notable advancement in targeted cancer therapies, yet identifying predictive biomarkers for treatment efficacy and resistance remains essential for optimizing clinical outcomes.
Methods: This systematic meta-analysis synthesized studies available through September 2024 across PubMed, Cochrane Library, SpringerLink, and Embase. Using CRISPR/Cas9 technology, this study generated cells with KEAP1 and STK11 knockouts, and utilized lentiviral vectors to overexpress PD-L1.
Alterations in newborn metabolite patterns with preterm birth and diabetes in pregnancy.
Pediatr Res
January 2025
Department of Pediatrics, Yale School of Medicine, Yale University, New Haven, CT, USA.
Background: This study examines the influence of prematurity and diabetes (DM) in pregnancy on metabolite patterns at birth, and associations with adiposity development in a prospective cohort.
Methods: Term and preterm (30-36 weeks gestational age [GA]) infants were enrolled and body composition assessments completed through discharge. Targeted metabolomics was used to assess metabolites in cord or infant blood in the first 2 days.
Molecular foundations for shear-induced dynamics of natural organic matter.
Sci Total Environ
January 2025
Department of Chemical Engineering, Tennessee Technological University, Cookeville, TN, United States. Electronic address:
The overall objective of the present work was to quantify how shear, coupled with varying salt concentration, affected the particle size distribution and relaxation/aggregation behavior for various organic sources of nonliving natural organic matter (NNOM) in surface water. NNOM has been implicated as a conditioning agent leading to the formation of biofilms such as algae. NNOM is also a responsible in surface waters for facilitated transport of a variety of anthropogenic pollutants.
View Article and Find Full Text PDFPrognostic value of manual versus automatic methods for assessing extents of resection and residual tumor volume in glioblastoma.
J Neurosurg
January 2025
1Department of Neurosurgery, St. Olav's University Hospital, Trondheim, Norway.
Objective: The extent of resection (EOR) and postoperative residual tumor (RT) volume are prognostic factors in glioblastoma. Calculations of EOR and RT rely on accurate tumor segmentations. Raidionics is an open-access software that enables automatic segmentation of preoperative and early postoperative glioblastoma using pretrained deep learning models.
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