AI Article Synopsis
- Angiocentric glioma (AG) is recognized in the 2007 WHO classification, showing unique ependymal and diffuse astrocytic traits along with low proliferation rates.
- A study presents three cases of AG in young children, with the first case displaying a higher proliferation index and mitotic activity but still achieving long-term survival without recurrence after six years.
- This research is notable for being the first to assess mitotic activity in AGs using the pHH3 immunostain technique.
Article Abstract
Angiocentric glioma (AG) has been formally codified in the revised 2007 WHO Classification of Tumours of the Central Nervous System. AGs characteristically exhibit mixed features of ependymal and diffuse astrocytic differentiation and low proliferation rates, with Ki-67 labeling indices ranging from less than 1 to 5%. A single case with anaplastic recurrence and a labeling index of 10% has been reported. In the present study, we report a series of three AGs (Case 1: 4-year-old girl at right frontal lobe; Case 2: 4-year-old boy at left frontal lobe; Case 3: 9-year-old boy at right temporal lobe). Case 1 with elevated proliferation index (~10%) and increased mitotic activity (six mitoses per 10 high-power fields) on phospho-histone H3 (pHH3) immunostain at presentation, nonetheless, has shown protracted recurrence-free survival after 6 years of follow-up. So far, this is the first report for evaluating the mitotic activity in AGs using pHH3 immunostain.
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| http://dx.doi.org/10.1007/s10014-011-0062-0 | DOI Listing |
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