The aim of the present study was to evaluate the status of apoptosis in peripheral blood leukocytes of dogs with demodicosis. A total of 26 dogs suffering from demodicosis, and positive for Demodex canis mites by skin scraping, participated in the study, 13 with localized demodicosis (LD) and 13 with generalized demodicosis (GD). A further 13 clinically healthy dogs, all of whom were negative for mites upon skin scraping, were used as controls. The dogs with GD revealed significantly higher (P ≤ 0.0001) percentage of leukocytes with externalization of phosphatidylserine (PS) and depolarized mitochondrial membrane potentials (ΔΨm) as compared with the dogs with LD and healthy controls. These dogs also revealed significantly lower values (P ≤ 0.0001) of hematological parameters viz. hemoglobin, total erythrocytes count total leukocytes count, lymphocytes, monocytes and neutrophils. Significantly higher (P ≤ 0.0001) percentages of leukocytes with externalization of PS and depolarized ΔΨm were also found in dogs with LD as compared with the healthy controls. These dogs also revealed significantly lower values of Hb (P ≤ 0.0001), TEC (P=0.025), TLC (P ≤ 0.0001), lymphocytes (P=0.008), monocytes (P ≤ 0.0001) and neutrophils (P=0.03). It is concluded that premature apoptosis of PBL may be implicated in the immunosuppression of the dogs with demodicosis.
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http://dx.doi.org/10.1016/j.vetimm.2011.08.008 | DOI Listing |
J Vasc Bras
October 2024
Universidade Estadual Paulista - UNESP, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.
Background: Abdominal aortic aneurysms (AAA) are 4-6 times more frequent among men than among women, but prognosis tends to be worse in women.
Objective: To compare endovascular procedures to repair infrarenal AAA in men and women, using data from a prospective registry.
Methods: This registry collected data from five university hospitals in the state of São Paulo (Brazil) from 2012 to 2022.
Cureus
June 2024
Medicine, Jonelta Foundation School of Medicine, University of Perpetual Help System DALTA, Las Piñas City, PHL.
This umbrella meta-analysis aims to investigate two surgical treatments for abdominal aortic aneurysm (AAA): endovascular aneurysm repair (EVAR) and open surgery repair (OSR). Our study aims to elucidate the 30-day mortality rate, reintervention rates, and aneurysm-related mortality in EVAR versus OSR for AAA. We conducted a comprehensive assessment of meta-analyses ( = 34 articles) comparing EVAR and OSR for AAA.
View Article and Find Full Text PDFMed Sci (Basel)
September 2023
Department of Medical Physics, Apollo Hospitals Bilaspur, Bilaspur 495006, India.
Background: Accurate dosimetry is crucial in radiotherapy to ensure optimal radiation dose delivery to the tumor while sparing healthy tissues. Traditional dosimetry techniques using homogeneous phantoms may not accurately represent the complex anatomical variations in cervical cancer patients, highlighting the need to compare dosimetry results obtained from different phantom models.
Purpose: The aim of this study is to design and evaluate an anthropomorphic heterogeneous female pelvic (AHFP) phantom for radiotherapy quality assurance in cervical cancer treatment.
Pak J Med Sci
January 2023
Huifang Zhu, Department of Thyroid Surgery and Vascular Surgery, Huzhou Central Hospital, Affiliated Central Hospital HuZhou University, Huzhou 313000, Zhejiang Province, P.R. China.
Objective: This meta-analysis was designed to assess if pre-operative low skeletal muscle mass impacts mortality rates of patients undergoing abdominal aortic aneurysm (AAA) repair.
Methods: Datasets of PubMed, CENTRAL, ScienceDirect, Embase, and Google Scholar were searched from 1 January 1980 to 15 December 2021 for studies assessing the role of low skeletal muscle mass on mortality rates of AAA repair. Studies measuring skeletal muscle mass on computed tomography scans and reporting long-term mortality (>1 year) were included.
Eur J Cancer
September 2022
Institut Gustave Roussy, University of Paris Saclay, Villejuif, France.
Background: The addition of either docetaxel or an androgen receptor signalling pathway inhibitor (ARSi) to androgen-deprivation therapy (ADT) has become the standard of care for metastatic castration-sensitive prostate cancer (mCSPC) patients. Recent phase III data support even greater survival impact of a triplet regimen with ADT plus docetaxel plus an ARSi (abiraterone or darolutamide) compared to ADT plus docetaxel.
Objective: To evaluate whether the addition of an ARSi to ADT improves outcomes of mCSPC patients treated with docetaxel.
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