A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma japonicum TSP-2, however, has been found to be highly polymorphic, perhaps diminishing the likelihood that this antigen can be used for vaccination against this species. Here, we examine polymorphism of the EC-2 of Sm-TSP-2 in genetically unique worms derived from six individuals from Kisumu, Kenya.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188324PMC
http://dx.doi.org/10.1016/j.ijpara.2011.07.007DOI Listing

Publication Analysis

Top Keywords

schistosoma mansoni
8
mansoni tetraspanin-2
8
polymorphism associated
4
associated schistosoma
4
tetraspanin-2 gene
4
gene vaccine
4
vaccine schistosomiasis
4
schistosomiasis contribute
4
contribute reducing
4
reducing 3-70
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!