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Mantle cell lymphoma: advances in biology and therapy.
Curr Opin Hematol
July 2008
Lymphoma Service, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Purpose Of Review: Mantle cell lymphoma is characterized by dysregulation of cyclin D1, but this is not sufficient for lymphoma development. It is a difficult disease to treat, being incurable with standard chemotherapy and having a median survival of approximately 5 years. The purpose of this review is to update recent advances in mantle cell lymphoma biology with prognostic and potentially therapeutic implications, and mantle cell lymphoma treatment approaches and new agents.
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