While small- and medium-sized commercial buildings (SMCBs) make up 96% of the commercial buildings in the U.S., serving a large variety of uses, little information is available on indoor air quality (IAQ) in SMCBs. This study investigated 37 SMCBs distributed across different sizes, ages, uses, and regions of California. We report indoor concentrations and whole building emission rates of a suite of 30 VOCs and aldehydes in these buildings. There was a considerable range in the concentrations for each of the contaminants, especially for formaldehyde, acetaldehyde, decamethylcyclopentasiloxane, d-limonene, 2-butoxyethanol, toluene, 2,2,4-trimethylpentanediol diisobutyrate, and diethylphthalate. The cause of higher concentrations in some building categories generally corresponded to expected sources, for example, chloroform was higher in restaurants and grocery stores, and formaldehyde was higher in retail stores and offices. Factor analysis suggests sources in SMCBs include automobile/traffic, cleaning products, occupant sources, wood products/coating, and plasticizers. The comparison to health guidelines showed that formaldehyde concentrations were above the chronic RELs required by the OEHHA (9 μg/m³) in 86% of the buildings. Data collected in this study begins to fill the knowledge gap for IAQ in SMCBs and helps us understand the indoor sources of VOCs to further improve indoor air quality in SMCBs.
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http://dx.doi.org/10.1021/es202132u | DOI Listing |
Curr Microbiol
January 2025
Industrial and Surface Engineering Laboratory, Bioprocess and Biointerfaces Team, Department of Life Sciences, Faculty of Sciences and Techniques, Sultan Moulay Slimane University, BP 523, 23000, Beni Mellal, Morocco.
Salmonella Typhi can adhere to and build biofilms on the surface of gallstones causing abnormal gallbladder mucosa, which could lead to carcinogenesis. The surface physicochemical properties of microbial cells and materials have been shown to play a crucial role in adhesion. Therefore, the purpose of this study was to investigate, for the first time, the surface properties of nine gallstones and to evaluate the influence of these parameters on the theoretical adhesion of S.
View Article and Find Full Text PDFCancer Cell
December 2024
Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address:
Molecular subtypes, such as defined by The Cancer Genome Atlas (TCGA), delineate a cancer's underlying biology, bringing hope to inform a patient's prognosis and treatment plan. However, most approaches used in the discovery of subtypes are not suitable for assigning subtype labels to new cancer specimens from other studies or clinical trials. Here, we address this barrier by applying five different machine learning approaches to multi-omic data from 8,791 TCGA tumor samples comprising 106 subtypes from 26 different cancer cohorts to build models based upon small numbers of features that can classify new samples into previously defined TCGA molecular subtypes-a step toward molecular subtype application in the clinic.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Otsuka Pharmaceutical Development & Commercialization Inc., Princeton, NJ, USA.
Background: Patients with dementia due to Alzheimer's disease may experience multiple different agitation symptoms - including excessive motor activity, verbal aggression, and physical aggression - at varying frequencies. The efficacy of brexpiprazole 2 or 3 mg/day on 29 individual agitation behaviors (Cohen-Mansfield Agitation Inventory [CMAI] items) was previously evaluated. Building upon that work, this post hoc analysis aimed to determine the efficacy of brexpiprazole on the same individual agitation behaviors, but specifically focusing on those patients who were frequently experiencing the behaviors at baseline.
View Article and Find Full Text PDFFront Aging Neurosci
December 2024
Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Background: Alzheimer's disease (AD) has a major negative impact on people's quality of life, life, and health. More research is needed to determine the relationship between age and the pathologic products associated with AD. Meanwhile, the construction of an early diagnostic model of AD, which is mainly characterized by pathological products, is very important for the diagnosis and treatment of AD.
View Article and Find Full Text PDFFront Public Health
January 2025
Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.
Background: The provision of high-quality healthcare services and patient satisfaction are fundamental objectives in modern healthcare. Humanistic nursing care, which emphasizes empathy, respect for individuality, and cultural sensitivity, aims to build trust and improve the overall experience for patients. This approach is especially relevant for rural patients in China, who often face additional challenges in accessing care in large tertiary hospitals.
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