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Design and synthesis of new prostaglandin D₂ receptor antagonists. | LitMetric

Design and synthesis of new prostaglandin D₂ receptor antagonists.

Bioorg Med Chem

Minase Research Institute, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan.

Published: September 2011

AI Article Synopsis

Article Abstract

To identify new cost-effective prostaglandin D₂ (DP) receptor antagonists, a series of novel 3-benzoylaminophenylacetic acids were synthesized and biologically evaluated. Among those tested, some representative compounds were found to be orally available. Receptor selectivity and rat PK profiles were also evaluated. The structure-activity relationship (SAR) study is presented.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2011.08.007DOI Listing

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