Ketamine is a unique anaesthetic because it has both hypnotic and analgesic effects and also potential hallucinogenic side effects. Lack of cardiopulmonary depression makes the drug a popular choice for anaesthesia in the prehospital setting. In recent years ketamine has been found to have anti-hyperalgesic and opioid saving effects, opening to new ways of managing post-operative and chronic pain states. Recreational use of ketamine among night clubbers is increasing and makes acute and chronic symptoms of ketamine abuse a new challenge in emergency departments.
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J Clin Med
December 2024
Department of Medical and Health Sciences Tarnobrzeg, State Higher Vocational School Memorial of Prof. Stanislaw Tarnowski in Tarnobrzeg, 39-400 Tarnobrzeg, Poland.
The World Health Organization (WHO) estimates that 180,000 patients die from burns every year, which is considered a serious public health issue. Patients with burns require immediate pre-hospital care and transport to specialized treatment facilities. The aim of this study was to outline the profile of the burn patient from the perspective of the Polish Medical Air Rescue (PMAR), as well as to analyze the medical procedures being implemented.
View Article and Find Full Text PDFBipolar depression is commonly accompanied by cognitive impairments. Transcranial direct current stimulation (tDCS) is emerging as a novel non-invasive treatment for bipolar depression. Given the portability and safety of tDCS, we developed a home-based protocol with real-time supervision.
View Article and Find Full Text PDFEur Neuropsychopharmacol
December 2024
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, ON, Canada; Mood Disorders Psychopharmacology Unit, Toronto Western Hospital - University Health Network, Toronto, ON, Canada; Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address:
Depression with comorbid posttraumatic stress disorder (PTSD) is associated with more severe symptoms and a reduced response to traditional treatments. Although ketamine shows promise as a rapid-acting antidepressant for treatment-resistant depression (TRD), its effectiveness in patients with comorbid PTSD remains underexplored. Therefore, we conducted a retrospective analysis of 134 patients from the Canadian Rapid Treatment Center of Excellence to compare the effectiveness of four ketamine infusions (0.
View Article and Find Full Text PDFJAMA Netw Open
December 2024
Fred Hutchinson Cancer Center, Seattle, Washington.
Importance: The psychological morbidity experienced by physicians, advanced practice practitioners (APPs), and nurses from working during the COVID-19 pandemic includes burnout, depression, and posttraumatic stress disorder (PTSD).
Objective: To investigate whether psilocybin therapy could improve symptoms of depression, burnout, and PTSD in US clinicians who developed these symptoms from frontline clinical work during the pandemic.
Design, Setting, And Participants: This double-blind randomized clinical trial enrolled participants from February to December 2022.
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