For the first time vital morphological structure of lacrimal gland was investigated based on spatial ultrasound digital examination. Structural characteristics of lacrimal gland are described considering anatomic topography and blood supply. These characteristics are analyzed based on planar and volumetric sonography depending on the patient age and pattern of changes. Their correlation is studied. The results of lacrimal gland examination allowed us to analyze a number of ultrasound diagnostic signs and compare them with changes in acute dacryoadenitis, MALT-lymphoma, Sjogren disease, sarcoidosis and thyroid eye disease. Revealed features may be useful for understanding of nature of clinical presentation. The results of the study may help to interpret diagnostic signs and follow up their evolution in a clinical course of a disease.

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