AI Article Synopsis
- A new sensitive method using (14)C radiolabeled precursors and beta-imager autoradiography was developed to study natural product biosynthesis in sponges.
- This research revealed that the biosynthetic intermediate oroidin contains components derived from specific amino acids.
- It is now suggested that proline and lysine serve as the initial building blocks for the pyrrole and 2-aminoimidazole parts of oroidin.
Article Abstract
Sponge natural product biosynthesis: A highly sensitive in vivo protocol based on (14)C radiolabeled precursors and beta-imager autoradiography allowed the unraveling of the origin of the pyrrole 2-aminoimidazole-containing key biosynthetic intermediate oroidin. Proline and lysine are now proposed as the early precursors of the pyrrole and the 2-aminoimidazole moieties of oroidin respectively.
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| http://dx.doi.org/10.1002/cbic.201100449 | DOI Listing |
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