AI Article Synopsis
- Sox6 plays a key role in determining muscle fiber types in vertebrates, specifically being repressed in slow-twitch muscle progenitors by the transcription factor Prdm1a.
- Researchers identified specific sequences in the sox6 gene that promote fast-twitch muscle expression when Prdm1a is active.
- While sox6 transcription is eventually derepressed in slow-twitch fibers, the protein itself is limited to fast-twitch fibers, regulated by miR-499, which is also controlled by Prdm1a, creating a feedback mechanism for slow-twitch muscle development.
Article Abstract
Sox6 has been proposed to play a conserved role in vertebrate skeletal muscle fibre type specification. In zebrafish, sox6 transcription is repressed in slow-twitch progenitors by the Prdm1a transcription factor. Here we identify sox6 cis-regulatory sequences that drive fast-twitch-specific expression in a Prdm1a-dependent manner. We show that sox6 transcription subsequently becomes derepressed in slow-twitch fibres, whereas Sox6 protein remains restricted to fast-twitch fibres. We find that translational repression of sox6 is mediated by miR-499, the slow-twitch-specific expression of which is in turn controlled by Prdm1a, forming a regulatory loop that initiates and maintains the slow-twitch muscle lineage.
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| http://dx.doi.org/10.1242/dev.070516 | DOI Listing |
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