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Proposal of a modified technique of Nikolsky's sign in oral autoimmune vesiculobullous diseases.
Front Oral Health
August 2024
Interdisciplinary Department of Medicine, School of Dentistry, University of Bari Aldo Moro, Bari, Italy.
Nikolsky's sign, originally described for skin lesions, presents challenges when applied to the oral mucosa. To address this, a modified Nikolsky's sign has been proposed specifically for the oral mucosa. In this variant, a gentle breath of air from the air syringe embedded in the dental unit is used to inflate a pre-existing collapsed blister (non-induced technique).
View Article and Find Full Text PDFStevens-Johnson syndrome-toxic epidermal necrolysis overlap in a patient taking quetiapine and famotidine: a case report.
J Med Case Rep
July 2024
Department of Pharmacy, Cathay General Hospital Medical Center, No 280, Sec 4, Renai Road, Taipei, 10630, Taiwan, Republic of China.
Article Synopsis
- Stevens-Johnson syndrome-toxic epidermal necrolysis (SJS-TEN) is a severe skin disorder that can be drug-induced, has a high mortality rate, and is characterized by widespread rashes, blisters, and mucosal involvement.
- An 82-year-old female patient experienced a rare delayed onset of SJS-TEN after starting famotidine and quetiapine, leading to extensive skin damage and eventual death 12 days after hospital admission.
- The case highlights the need for greater clinical awareness of potential drug side effects, the importance of timely supportive care, and the necessity for further research to establish effective management guidelines for SJS-TEN.
Serum interleukin-6 concentration in patients with pemphigus.
Dermatol Reports
June 2024
Department of Dermatology, University of Medicine and Pharmacy, Ho Chi Minh City.
Pemphigus is a rare blistering autoimmune disease that damages the integumentary system and lowers the quality of life of patients. Interleukin-6 (IL-6) has been linked to the immunopathogenesis of pemphigus, according to recent research. Thus, the investigation purpose was to assess the function of IL-6 in the development and intensity of pemphigus disease.
View Article and Find Full Text PDFBeyond the Surface: A Clinical Insight Into a 60-Year-Old Male With Pemphigus vulgaris.
Cureus
February 2024
Internal Medicine, Family Medicine, Larkin Community Hospital Palm Springs Campus, Hialeah, USA.
Pemphigus vulgaris, a rare and life-threatening autoimmune disorder, presents with painful skin and mucosal lesions, leading to blistering sores attributed to acantholysis. This study delves into the clinical manifestations, risk factors, and diagnostic intricacies associated with pemphigus vulgaris, with a focus on a representative case highlighting the challenges in its recognition and management. We explore the case of a 60-year-old male with pemphigus vulgaris, whose initial presentation involved yellow-crusting lesions on the scalp progressing to non-pruritic lesions on the chest, neck, and inguinal areas.
View Article and Find Full Text PDFEffects of the Heterodimeric Neurotoxic Phospholipase A from the Venom of on the Contractility of Rat Papillary Muscles and Thoracic Aortas.
Toxins (Basel)
February 2024
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia.
Phospholipases A (PLAs) are a large family of snake toxins manifesting diverse biological effects, which are not always related to phospholipolytic activity. Snake venom PLAs (svPLAs) are extracellular proteins with a molecular mass of 13-14 kDa. They are present in venoms in the form of monomers, dimers, and larger oligomers.
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