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High sacral slope, lumbar lordosis, and sacral slope-to-pelvic incidence ratio are associated with new bone formation in ankylosing spondylitis.
Turk J Med Sci
December 2024
Department of Rheumatology, Faculty of Medicine, Marmara University, İstanbul, Turkiye.
Background/aim: Syndesmophyte formation appears to be site-specific in ankylosing spondylitis (AS) and new bone formation seems to occur in regions of microtrauma that are prone to tensile forces. Pelvic and spinal parameters are unique for each individual. Pelvic tilt and sacral slope are important anatomical features that compensate in harmony in keeping the sagittal balance.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze how changes in upper lumbar lordosis after spinal fusion affect the alignment of unfused lower lumbar segments in patients with Adolescent Idiopathic Scoliosis.
- A retrospective review was conducted on 158 patients who underwent posterior spinal fusion, focusing on various spinal measurements and using MATLAB for 3D calculations.
- Results indicated that increased upper lumbar lordosis influenced the lordotic shape of distal unfused segments, with varying impacts based on the specific levels of fusion, while overall sagittal alignment remained stable.
Samelisant (SUVN-G3031), a histamine 3 receptor inverse agonist: Results from the phase 2 double-blind randomized placebo-controlled study for the treatment of excessive daytime sleepiness in adult patients with narcolepsy.
Sleep Med
December 2024
Bogan Sleep Consultants, LLC, Columbia, SC, USA.
Narcolepsy is a rare, chronic neurological disorder characterized by a dysregulated sleep-wake cycle, with core clinical features including excessive daytime sleepiness (EDS), cataplexy, hypnopompic/hypnagogic hallucinations, and sleep paralysis. Several treatment options are available for the symptomatic management of narcolepsy, but they have limitations. Comorbidities of narcolepsy further limit the treatment choices.
View Article and Find Full Text PDFDifferential electrographic seizure patterns in malformations of cortical development, early life brain injury, and later life brain injury.
Epilepsy Res
December 2024
Department of Neurology, University of Pittsburgh School of Medicine, 3471 Fifth Ave, Pittsburgh, PA 15213, USA. Electronic address:
Article Synopsis
- Structural epilepsy can result from brain injuries during early or late life and is linked to epilepsy due to malformations of cortical development.
- A study of 70 adults found that those with later life brain injuries experienced longer and less frequent seizures compared to those with malformations or early life injuries.
- The research showed that later life injuries resulted in different seizure types, with a higher frequency of focal to bilateral tonic-clonic seizures and lower rates of seizures starting in both hemispheres.
International Clinical Practice Guideline Recommendations for Acute Pulmonary Embolism: Harmony, Dissonance, and Silence.
J Am Coll Cardiol
October 2024
Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Article Synopsis
- Despite advancements in clinical practices, pulmonary embolism (PE) remains a significant challenge in diagnosis and treatment due to factors like aging populations and health disparities.
- Clinicians often rely on various international guidelines for managing PE, but inconsistencies and gaps in recommendations can lead to confusion.
- This review focuses on key similarities and differences in PE guidelines and emphasizes the need for clearer management strategies and further research in this area.
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