Objective: To evaluate the possible association between peripheral levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) with immediate and delayed verbal recall in a group of recurrent depressed women.
Methods: Logical Memory Subtests of the Wechsler Memory Scale - Revised was administered to 30 patients with recurrent major depressive disorder with no clinical and psychiatric comorbidities. Blood samples were collected from 8:00 am to 9:00 am, before memory assessments.Plasma was stored and ELISA assay was used to detect IL-6 and TNF-alpha levels.
Results: There was a statistically significant association between IL-6 levels and immediate verbal recall (IVR) (B=-0.787, p=0.000) and delayed verbal recall (DVR) (B=-0.695, p=0.001) even after controlling for age, depression severity and body mass index.
Conclusion: The results of this study indicated that low performances in IVR and DVR are associated with higher IL-6 levels in women with recurrent MDD. The results of this study suggest the existence of an association between inflammatory imbalance and cognitive impairment in MDD.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Verbal Encoding Strategies in Visuo-Spatial Working Memory.
J Cogn
January 2025
Department of Psychology, Humboldt-Universität zu Berlin, Berlin, DE.
Visual working memory and verbal storage are often investigated independently of one another. However, a growing body of evidence suggests that naming visual stimuli can provide an advantage in performance during visual working memory tasks. On the other hand, there is also evidence that labeling could lead to biases in recall.
View Article and Find Full Text PDFDelayed primacy recall in AVLT is associated with medial temporal tau PET burden in cognitively unimpaired adults.
Cortex
January 2025
School of Psychology, Liverpool John Moores University, United Kingdom.
Background: Alzheimer's disease (AD) can be diagnosed by in vivo abnormalities of amyloid-β plaques (A) and tau accumulation (T) biomarkers. Previous studies have shown that analyses of serial position performance in episodic memory tests, and especially, delayed primacy, are associated with AD pathology even in individuals who are cognitively unimpaired. The earliest signs of cortical tau pathology are observed in medial temporal lobe (MTL) regions, yet it is unknown if serial position markers are also associated with early tau load in these regions.
View Article and Find Full Text PDFDevelopment of novel patient-reported outcome instruments to assess atopic dermatitis-associated dyspigmentation and xerosis in patients with skin of colour.
Br J Dermatol
January 2025
Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
Background: The prevalence and burden of atopic dermatitis (AD) are disproportionately high in individuals with skin of colour (SOC). Previous research shows that risk for xerosis and/or dyspigmentation is heightened in this population and may be more bothersome. However, there are no patient-reported instruments developed specifically for these disease sequelae in patients with SOC.
View Article and Find Full Text PDFNeuropsychological test performance in mild cognitive impairment with Lewy bodies: A systematic review and meta-analysis.
Alzheimers Dement
January 2025
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Stockholm, Sweden.
Background: We sought to characterize the cognitive profile among individuals with mild cognitive impairment with Lewy bodies (MCI-LB) to help guide future clinical criteria.
Methods: Systematic review and meta-analysis included MCI-LB studies with cognitive data from PubMed, Embase, Web of Science, and PsycINFO (January 1990 to March 2023). MCI-LB scores were compared to controls, MCI due to Alzheimer's disease (MCI-AD), and dementia with Lewy bodies (DLB) groups with random-effects models.
Verbal Memory is Higher After Aerobic Exercise When Compared to Muscle Stretching.
Am J Lifestyle Med
January 2025
Department of Psychology, Central Michigan University, Mt. Pleasant, MI, USA (GTR, JAP, HO).
Acute exercise is linked to memory improvement. Several mediators may influence the effect of exercise such as the type of exercise (aerobic exercise, muscle stretching). The primary aim was to analyze memory outcomes after a 20-min bout of aerobic exercise or muscle stretching.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!