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The Canadian Genomics Research and Development Initiative for Antimicrobial Resistance (GRDI-AMR) uses a genomics-based approach to understand how health care, food production and the environment contribute to the development of antimicrobial resistance. Integrating genomics contextual data streams across the One Health continuum is challenging because of the diversity in data scope, content and structure. To better enable data harmonization for analyses, a contextual data standard was developed.
View Article and Find Full Text PDFEffect of ultrasonic-assisted enzymatic extraction on proso millet bran protein: extraction rate, structural and functional properties.
J Sci Food Agric
January 2025
College of Food Science and Engineering, Northwest A&F University, Yangling, China.
Background: Proso millet bran protein (PMBP), derived from agricultural by-products, possesses high nutritional value, despite its challenging extraction process. The present study proposes an extraction method for PMBP using ultrasound-assisted cellulase technology (UAE), and optimizes the process parameters. Non-waxy (N-PMBP) and waxy (W-PMBP) PMBPs, extracted through alkaline solubilization and acid precipitation (conventional treatment, CT), served as control groups to assess the impact of UAE on the structure and functionality of PMBP, as well as the distinctions between N-PMBPs and W-PMBPs.
View Article and Find Full Text PDFImmunogenicity and vaccine efficacy of -derived extracellular vesicles as a novel vaccine candidate.
Virulence
December 2025
Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea.
(APP) is a significant pathogen in the swine industry, leading to substantial economic losses and highlighting the need for effective vaccines. This study evaluates the potential of APP-derived extracellular vesicles (APP-EVs) as a vaccine candidate compared to the commercial Coglapix vaccine. APP-EVs, isolated using tangential flow filtration (TFF) and cushioned ultracentrifugation, exhibited an average size of 105 nm and a zeta potential of -17.
View Article and Find Full Text PDFDietary polyphenols for tumor therapy: bioactivities, nano-therapeutic systems and delivery strategies.
Food Funct
January 2025
Shandong Provincial Key Laboratory of Animal Resistance Biology, Key Laboratory of Food Nutrition and Safety of Shandong Normal University, College of Life Sciences, Shandong Normal University, Jinan, 250014, PR China.
Various dietary polyphenols have demonstrated potent anti-tumor properties and are being evaluated as potential adjuncts in cancer treatment. Although several reviews have offered extensive insights into the anti-tumor activities of dietary polyphenols, they frequently lack a detailed discussion on the design of therapeutic protocols and targeted delivery strategies of these compounds, which impedes the translation of their biological activity into clinical practice. This article aims to deliver a comprehensive review of the anti-tumor properties of dietary polyphenols, while also examining the design and implementation of nanotherapy systems based on these compounds.
View Article and Find Full Text PDFBurden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021.
World J Psychiatry
January 2025
Department of Health Management Centre, Zhongshan Hospital, Fudan University, Shanghai 200030, China.
Background: The burden of mental disorders (MD) in the Western Pacific Region (WPR) remains a critical public health concern, with substantial variations across demographics and countries.
Aim: To analyze the burden of MD in the WPR from 1990 to 2021, along with associated risk factors, to reveal changing trends and emerging challenges.
Methods: We used data from the Global Burden of Disease 2021, analyzing prevalence, incidence, and disability-adjusted life years (DALYs) of MD from 1990 to 2021.
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