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Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer.
J Transl Med
January 2025
Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
Background: Drug resistance constitutes one of the principal causes of poor prognosis in breast cancer patients. Although cancer cells can maintain viability independently of mitochondrial energy metabolism, they remain reliant on mitochondrial functions for the synthesis of new DNA strands. This dependency underscores a potential link between mitochondrial energy metabolism and drug resistance.
View Article and Find Full Text PDFIdentification of novel serum lipid metabolism potential markers and metabolic pathways for oral cancer: a population-based study.
BMC Cancer
January 2025
Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, 1 Xueyuan Road, Fujian, 350108, China.
Objective: This study aims to identify potential lipid biomarkers and metabolic pathways associated with oral cancer (OC). Then to establish and evaluate disease classification models capable of distinguishing OC patients from healthy controls.
Methods: A total of 41 OC patients and 41 controls were recruited from a hospital in Southeast China to examine the serum lipidomics by Ultra-high Performance Liquid Chromatography Q Exactive Mass Spectrometry (UHPLC-QE-MS).
Targeting ABCD1-ACOX1-MET/IGF1R axis suppresses multiple myeloma.
Leukemia
January 2025
Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.
Multiple myeloma (MM) remains an incurable hematological malignancy that necessitates the identification of novel therapeutic strategies. Here, we report that intracellular levels of very long chain fatty acids (VLCFAs) control the cytotoxicity of MM chemotherapeutic agents. Inhibition of VLCFA biosynthesis reduced cell death in MM cells caused by the proteasome inhibitor, bortezomib.
View Article and Find Full Text PDFIdentification and Screening of Trace and Multityped Solvents Using Transpiration-Driven Electrokinetic Generation Principle.
Nano Lett
January 2025
School of Physical Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.
Transpiration-driven electrokinetic power generators (TEPGs) hold promising potential for intelligent chemical sensing applications, enabling the efficient identification and screening of organic solvents. Here, we report a novel TEPG-based chemical sensor using MoS-doped cellulose filter paper for efficient detection of poplar solvents like water, alcohols, and methanol. TEPGs operate by leveraging capillary-driven transpiration to induce solvent flow through porous materials, leading to ion migration and the formation of electrical double layers (EDLs) at the solid-liquid interfaces.
View Article and Find Full Text PDFPrevalence and network structure of depression, anxiety and adverse doctor-patient relationship risks among patients with physical diseases: A cross-sectional study.
J Affect Disord
January 2025
Clinical Mental Health Department, The First Hospital of Hebei Medical University, Hebei, China; The Key Laboratory of Brain Sciences and Psychology, Hebei, China. Electronic address:
Background: Mental health issues among patients with physical diseases are increasingly common. This study investigated the prevalence of depression, anxiety, and adverse doctor-patient relationship risks (ADRR) among patients with physical diseases, and the central and bridge symptoms of this network structure.
Methods: A total of 14,344 patients with physical diseases enrolled in this survey.
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