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Background: The goal of this study was to examine the effects of spinal cord stimulation (SCS) on muscle activity during walking after lower-limb amputation. Amputation results in a loss of sensory feedback and alterations in gait biomechanics, including co-contractions of antagonist muscles about the knee and ankle, and reduced pelvic obliquity range-of-motion and pelvic drop. SCS can restore sensation in the missing limb, but its effects on muscle activation and gait biomechanics have not been studied in people with lower-limb amputation.

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When playing on an sloped golf course, the ball often misses the hole to the front-lower side, which is also referred to as the "amateur side." This can be attributed to the difficulty in perceiving the green slope and choosing the appropriate launch direction and ball speed, especially for amateurs. The study had three main objectives.

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A mechanosensitive circuit of FAK, ROCK, and ERK controls biomineral growth and morphology in the sea urchin embryo.

Proc Natl Acad Sci U S A

January 2025

Department of Marine Biology, Charney School of Marine Sciences, University of Haifa, Haifa 3498838, Israel.

Biomineralization is the utilization of different minerals by a vast array of organisms to form hard tissues and shape them in various forms. Within this diversity, a common feature of all mineralized tissues is their high stiffness, implying that mechanosensing could be commonly used in biomineralization. Yet, the role of mechanosensing in biomineralization is far from clear.

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Accurate control of force on the environment is mechanically necessary for many tasks involving the lower extremities. We investigated drifts in the horizontal (shear) active force produced by right-footed seated subjects and the effects of force matching by the other foot. Subjects generated constant shear force at 15% and 30% of maximal voluntary contraction (MVC) using one foot.

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Vaginal Orthosis After Native Tissue Reconstructive Surgery: Design and Phase 0.

Urogynecology (Phila)

December 2024

From the Division of Urogynecology and Reconstructive Pelvic Surgery, University of Alabama at Birmingham, Birmingham, AL.

Importance: Pelvic organ prolapse recurrence following native tissue repair occurs with composite failure rates of 9-19% within 12 months, predominantly involving apical/anterior compartments. Objective The objective of this study was to develop a novel vaginal orthosis (NVO) device prototype through an iterative design process based on investigator and user feedback.

Study Design: The NVO was designed based on pelvic floor biomechanical principles to mitigate unopposed intra-abdominal pressure of the anterior vagina by absorbing and redirecting intra-abdominal forces to the levator ani and tailored to accommodate postoperative vaginal caliber and axis.

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