Cerebrospinal fluid (CSF) rhinorrhea is the most common complication after transsphenoidal pituitary surgery. The authors compare their previous experience using an autologous fat graft and lumbar drain placement in 107 patients with their current technique of using a dural sealant and collagen matrix in 97 patients to prevent postoperative CSF leak after pituitary tumor resection. The failure rate for CSF leak repairs between the two groups was similar. The use of a dural sealant and collagen matrix, however, has the advantages of decreased length of hospital stay, decreased length of Intensive Care Unit stay, avoidance of the morbidity of an extra abdominal incision, and avoidance of the risks of lumbar CSF drainage.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jocn.2011.04.005DOI Listing

Publication Analysis

Top Keywords

dural sealant
12
sealant collagen
12
transsphenoidal pituitary
8
pituitary surgery
8
cerebrospinal fluid
8
collagen matrix
8
csf leak
8
decreased length
8
polyethylene glycol
4
glycol peg
4

Similar Publications

Role of CT myelography in the diagnosis and management of spontaneous intracranial hypotension.

Clin Neurol Neurosurg

December 2024

CHU de Lille, 2 Avenue Oscar Lambret, Hauts-de-France, France. Electronic address:

Introduction: Spontaneous intracranial hypotension (SIH) is a secondary cause of headache. Its pathophysiology is complex, and relies mainly on the notion of a localized leak, and thus a loss of cerebrospinal fluid (CSF) in the spinal region. SIH is little known to the medical profession, for which CT myelography is a technique on the rise, allowing to identify and treat the leak using a blood-patch or a fibrin sealant.

View Article and Find Full Text PDF
Article Synopsis
  • The study evaluates the in vivo degradation and effectiveness of a photocrosslinkable hyaluronic acid (HA)-based dural sealant in preventing cerebrospinal fluid (CSF) leakage using MRI and histopathological analysis.
  • HA photosealants were applied to rat dura after a surgical procedure and showed quick sealing upon light exposure, with degradation monitored through MRI scans over 4 weeks.
  • Results indicated that the HA photosealants gradually degraded while effectively preventing CSF leakage and showed no adverse effects on surrounding tissue, suggesting strong potential for clinical use in dural repair.
View Article and Find Full Text PDF
Article Synopsis
  • Incidental durotomy (ID) is a common issue in spine surgeries that can lead to longer hospital stays and complications like pseudomeningocele formation, prompting a study comparing traditional open vs. minimally invasive (MIS) microdiscectomy techniques.
  • The study included 192 MIS patients and 2902 open surgery patients, ultimately analyzing 156 matched patients from both groups for ID occurrences and complications.
  • Results showed a similar incidence rate of ID in both methods (3.1% total), with one re-operation in the open cohort for pseudomeningocele, but no significant difference in re-operation rates between the two groups, highlighting the need for more extensive future research.
View Article and Find Full Text PDF

Purpose: Surgery close to or in contact with the ventricular system is challenging due to the complications. We sought to evaluate the effectiveness and safety of TachoSil® as a ventricular sealant in preventing complications after cranial surgery with an open ventricular system (OVS).

Methods: This is a single-center and prospective cohort study We included patients who underwent elective surgery for supratentorial craniotomy and periventricular pathology between December 2020 and November 2023.

View Article and Find Full Text PDF

Chiropractic spinal manipulation therapy (CSMT) of the cervical spine has been reported to cause mechanical dural injuries that result in cerebrospinal fluid (CSF) leaks. We present a case of symptomatic intracranial hypotension after isolated thoracic CSMT. Initial imaging was unable to definitively localize the CSF leak, but dynamic imaging was able to better identify the defect.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!