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Refractory Chronic Diffuse Granular Myringitis with Medial Meatal Stenosis.
J Int Adv Otol
September 2024
Department of Otorhinolaryngology, Hospital Raja Permaisuri Bainun, Ipoh, Perak, Malaysia.
Article Synopsis
- - Granular myringitis is a persistent inflammation of the eardrum that doesn't affect the middle ear, and there isn’t a standard treatment for it.
- - A 60-year-old woman with persistent ear discharge and hearing loss was initially treated with antibiotics but showed no improvement, leading to a decision for surgery due to complications and impact on her life.
- - Surgical treatment involved removing granulation tissue and improving the ear canal, resulting in symptom resolution and a better quality of life, indicating the approach's potential for chronic cases, though more research is needed on long-term effects.
Vedolizumab plus basiliximab as second-line therapy for steroid-refractory lower gastrointestinal acute graft-versus-host disease.
Front Immunol
July 2024
Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Background: Steroid-resistant (SR) lower gastrointestinal (LGI) tract graft-versus-host disease (GVHD) is the predominant cause of morbidity and mortality from GVHD after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The role of vedolizumab in the treatment of SR-LGI acute GVHD (aGVHD) remains uncertain. We aimed to assess the efficacy and safety of vedolizumab combined with basiliximab as second-line therapy for SR-LGI-aGVHD.
View Article and Find Full Text PDFThe management of infection: from empirism to evidence.
Med Pharm Rep
January 2024
2 Department of Internal Medicine, Emergency Clinical County Hospital, Cluj-Napoca, Romania.
infection (CDI) in clinical practice represents a challenge for its management and also prevention of recurrence. Even though there are updated guidelines for infection prevention, control and treatment, CDI remains a leading cause of healthcare acquired diarrhea with increasing incidence in the community. We present here a synthesis of the most recent international guidelines on the management of CDI.
View Article and Find Full Text PDFThe clinical symptoms of an immune checkpoint inhibitor (ICI)-induced colitis are similar to those of ulcerative colitis. ICI-induced colitis, like ulcerative colitis, may be complicated by other colitis, such as infection (CDI). A 72-year-old man was admitted because of watery and bloody stools 10 times a day after three courses of nivolumab (antibodies against programmed death 1) and ipilimumab (cytotoxic T-lymphocyte-associated antigen-4) for stage IV renal cell carcinoma.
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