To develop and test theory-based procedures for modeling two-phase flow through fractures, it is important to be able to compare computational results for a fracture with experiments performed on the exact same fracture. Unfortunately for real fractures, any attempt to image the fracture and to produce a numerical model of the fracture accessible to computer modeling unavoidably results in a coarsening of the resolution, with the very small-scale features of the imaged fracture averaged to produce the numerical representation used in modeling. Contrary to the hope that these high-resolution features would be unimportant, several modeling efforts have shown that such changes in resolution do affect the flow. Therefore, the numerical representation is different from the real fracture because of this unavoidable coarsening of the resolution. To remove the problems caused by the use of different fractures in the experiment and in the model, the fracture used in our experiments was stereographically constructed from the same numerical representation used in the modeling so that the only difference between the experimental "fracture" and the modeling "fracture" is a manufacturing error of approximately 3% or less in the aperture sizes of the manufactured experimental model. Using several models not unlike others in the literature, we modeled injection of air into the water-saturated fracture. The modeling results are compared to experimental results for injection of air into the water-saturated stereolithographically constructed fracture. A comparison between modeling and experimental results for the essentially identical fractures shows a much better detailed agreement than obtained in other studies, which compared experimental flows on the real fracture with modeling results for a lower resolution representation of the real fracture. This suggests that many of the differences between experiment and modeling in previous work resulted from the differences between the experimental and modeling fractures. For our low capillary-number cases, the best agreement with experiment is for a modification of invasion percolation with trapping (IPwt) that included approximations to viscosity ratio effects and to the interfacial tension effects in reducing very short-range curvature.
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http://dx.doi.org/10.1103/PhysRevE.84.016316 | DOI Listing |
JAMA Intern Med
January 2025
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Importance: Evidence on cardiovascular benefits and safety of sodium-glucose cotransporter 2 (SGLT-2) inhibitors is mainly from placebo-controlled trials. Therefore, the comparative effectiveness and safety of individual SGLT-2 inhibitors remain unknown.
Objective: To compare the use of canagliflozin or dapagliflozin with empagliflozin for a composite outcome (myocardial infarction [MI] or stroke), heart failure hospitalization, MI, stroke, all-cause death, and safety outcomes, including diabetic ketoacidosis (DKA), lower-limb amputation, bone fracture, severe urinary tract infection (UTI), and genital infection and whether effects differed by dosage or cardiovascular disease (CVD) history.
Orthopadie (Heidelb)
January 2025
Klinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Freiburg, Deutschland.
Background: Patients who have had prior injections, surgeries such as arthroscopies, and have existing osteosynthetic implants in the hip and knee have an increased risk of periprosthetic infections when undergoing hip (THA) or total knee arthroplasty (TKA).
Osteosynthesis: For patients with osteosynthetic implants in the knee joint, a two-stage procedure (implant removal followed by TKA) is recommended based on the available literature and the high colonization rates. A two-stage procedure is also recommended for patients with hip implants.
J Trauma Acute Care Surg
January 2025
Division of Pediatric General, Thoracic and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
J Craniofac Surg
January 2025
Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Baghdad, Bab- Almoadham, Medical City.
Pterygomaxillary separation (PMS) is an important step in Le Fort I osteotomy procedure, without which complete mobilization of the maxilla cannot be achieved. The aim of this study was to evaluate PMS patterns and their relationship with the anatomic measurements in Le Fort I osteotomy. In this prospective observational study cone beam computed tomography (CBCT) was used to measure the anatomic variables of the pterygomaxillary junction (PMJ) region including thickness, width, the distance between the most concave point at the lateral surface of PMJ and the greater palatine foramen (C-GPF), and the angle preoperatively, and the separation patterns postoperatively divided into the clean-cut type, maxillary sinus type, and the pterygoid fracture type.
View Article and Find Full Text PDFBackground: As the prevalence of osteoporotic fractures increases, impacting the health of the aging population significantly, understanding the genetic link between chronic diseases such as primary biliary cholangitis (PBC) and osteoporosis (OP) is crucial. Despite existing research, the direct genetic relationship between these conditions remains unclear.
Materials And Methods: This study used a two-sample Mendelian randomization approach, drawing on the largest available genome-wide association studies.
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