Within the scope of a thermodynamic description using the maximum entropy production principle, transitions from one nonequilibrium (kinetic) regime to another are considered. It is shown that in the case when power-law dependencies of thermodynamic flux on force are similar for two regimes, only a transition accompanied by a positive jump of thermodynamic flux is possible between them. It is found that the difference in powers of the dependencies of thermodynamic fluxes on forces results in a number of interesting nonequilibrium transitions between kinetic regimes, including the reentrant one with a negative jump of thermodynamic flux.
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http://dx.doi.org/10.1103/PhysRevE.84.011113 | DOI Listing |
mSystems
January 2025
Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Gluconeogenesis, the reciprocal pathway of glycolysis, is an energy-consuming process that generates glycolytic intermediates from non-carbohydrate sources. In this study, we demonstrate that robust and efficient gluconeogenesis in bacteria relies on the allosteric inactivation of pyruvate kinase, the enzyme responsible for the irreversible final step of glycolysis. Using the model bacterium as an example, we discovered that pyruvate kinase activity is inhibited during gluconeogenesis via its extra C-terminal domain (ECTD), which is essential for autoinhibition and metabolic regulation.
View Article and Find Full Text PDFMembranes (Basel)
January 2025
Department of Biophysics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 19 H. Jordan Str., 41-808 Zabrze, Poland.
One of the most important formalisms used to describe membrane transport is Onsager-Peusner thermodynamics (TOP). Within the TOP framework, a procedure has been developed for the transformation of the Kedem-Katchalsky (K-K) equations for the transport of binary electrolytic solutions across a membrane into the Kedem-Katchalsky-Peusner (K-K-P) equations. The membrane system with an Ultra Flo 145 Dialyser membrane used for hemodialysis and aqueous NaCl solutions was used as experimental setup.
View Article and Find Full Text PDFCurr Med Chem
January 2025
Department of Pharmaceutical Sciences, Shalom Institute of Health & Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, 211007, Uttar Pradesh, India.
Background: Thymoquinone (TQ) is found in the seeds of Nigella sativa. It has immunomodulatory, antibacterial, anti-inflammatory, antioxidant, astringent, antifungal, and antihistaminic properties, making it a highly valuable compound of interest. However, the use of it as a therapeutic drug is highly challenging because of its poor solubility, low bioavailability, and short-term stability.
View Article and Find Full Text PDFChaos
January 2025
Department of Civil Engineering, The University of Hong Kong, HKSAR 999077, China.
Porous earth materials exhibit large-scale deformation patterns, such as deformation bands, which emerge from complex small-scale interactions. This paper introduces a cross-diffusion framework designed to capture these multiscale, multiphysics phenomena, inspired by the study of multi-species chemical systems. A microphysics-enriched continuum approach is developed to accurately predict the formation and evolution of these patterns.
View Article and Find Full Text PDFMetab Eng
January 2025
Biochemistry, Molecular, Cellular, and Developmental Graduate Group, University of California, Davis, Davis, CA, 95616, USA; Department of Chemistry, University of California, Davis, Davis, CA, 95616, USA. Electronic address:
D-allose is a rare monosaccharide, found naturally in low abundances. Due to its low-calorie profile and similar taste to sucrose, D-allose has the potential to become an ideal sugar substitute. D-allose also displays unique properties and health benefits that can be applied to various fields, including food and medicine.
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