AI Article Synopsis
- Chitosan nanogels were created using biocompatible materials through a template chemical cross-linking method involving polyion complex (PIC) micelle nanoreactors.
- The PIC were formed by combining chitosan with a specific block copolymer, leading to small nanoreactors approximately 50 nm in diameter and low variability.
- The successful formation and characteristics of the nanogels were validated using techniques like NMR, DLS, and TEM, with genipin's amount playing a crucial role in adjusting the size of the final nanogels in solution.
Article Abstract
Chitosan covalent nanogels cross-linked with genipin were prepared by template chemical cross-linking of chitosan in polyion complex micelle (PIC) nanoreactors. By using this method, we were able to prepare chitosan nanogels using only biocompatible materials without organic solvents. PIC were prepared by interaction between chitosan (X(n) = 23, 44, and 130) and block copolymer poly(ethylene oxide)-block-poly[sodium 2-(acrylamido)-2-methylpropanesulfonate] (PEO-b-PAMPS) synthesized by single-electron transfer-living radical polymerization (SET-LRP). PIC with small size (diameter about 50 nm) and low polydispersity were obtained up to 5 mg/mL. After cross-linking of chitosan with genipin, the nanoreactors were dissociated by adding NaCl. The dissociation of the nanoreactors and the formation of the nanogels were confirmed by (1)H NMR, DLS, and TEM. The size of the smallest nanogels was about 50 nm in the swollen state and 20 nm in the dry state. The amount of genipin used during reticulation was an important parameter to modulate the size of the nanogels in solution.
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