AI Article Synopsis
- Studies over the last decade show that tumour growth is influenced not only by cancer cells but also by their surrounding environment, known as the tumour microenvironment.
- The tumour microenvironment consists of various cell types, including fibroblasts, immune cells, and mesenchymal stem cells (MSC), which can impact cancer progression.
- The relationship between MSC and tumour cells is complex and debated, as MSCs can either promote or inhibit tumor growth, making their role in cancer a topic of ongoing research.
Article Abstract
Over the last decade, genetic and cell biology studies have indicated that tumour growth is not only determined by malignant cancer cells themselves, but also by the tumour microenvironment. Cells present in the tumour microenvironment include fibroblasts, vascular, smooth muscle, adipocytes, immune cells and mesenchymal stem cells (MSC). The nature of the relationship between MSC and tumour cells appears dual and whether MSC are pro- or anti-tumorigenic is a subject of controversial reports. This review is focused on the role of MSC and bone marrow (BM) niches in cancer.
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| http://dx.doi.org/10.1007/s12094-011-0706-x | DOI Listing |
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