The presence of gene-environment statistical interaction (GxE) and correlation (rGE) in biological development has led both practitioners and philosophers of science to question the legitimacy of heritability estimates. The paper offers a novel approach to assess the impact of GxE and rGE on the way genetic and environmental causation can be partitioned. A probabilistic framework is developed, based on a quantitative genetic model that incorporates GxE and rGE, offering a rigorous way of interpreting heritability estimates. Specifically, given an estimate of heritability and the variance components associated with estimates of GxE and rGE, I arrive at a probabilistic account of the relative effect of genes and environment.
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http://dx.doi.org/10.1007/s10441-011-9139-8 | DOI Listing |
Mol Psychiatry
November 2024
Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Dev Psychopathol
February 2023
Behavioral Science Institute, Radboud University, Nijmegen, The Netherlands.
PLoS Genet
November 2020
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.
Polygenic scores are increasingly powerful predictors of educational achievement. It is unclear, however, how sets of polygenic scores, which partly capture environmental effects, perform jointly with sets of environmental measures, which are themselves heritable, in prediction models of educational achievement. Here, for the first time, we systematically investigate gene-environment correlation (rGE) and interaction (GxE) in the joint analysis of multiple genome-wide polygenic scores (GPS) and multiple environmental measures as they predict tested educational achievement (EA).
View Article and Find Full Text PDFDrug Alcohol Depend
April 2020
Behavioural Science Institute, Radboud University Nijmegen, the Netherlands.
Twin Res Hum Genet
December 2019
Department of Psychology, Southern Illinois University Carbondale, Carbondale, IL, USA.
This article reviews the Southern Illinois Twins/Triplets and Siblings Study (SITSS) and describes some of the findings related to recent projects that were completed using this sample. At this time, the SITSS has enrolled 375 twin pairs, 12 triplet families, 1 family of quadruplets, 98 nontwin sibling pairs and 287 singletons. Testing begins for twins and triplets as young as age 1 and then occurs yearly on their birthdays until 5 years of age.
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