One-pot three-enzyme synthesis of UDP-GlcNAc derivatives.

Chem Commun (Camb)

Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA.

Published: October 2011

A Pasteurella multocida N-acetylglucosamine 1-phosphate uridylyltransferase (PmGlmU) was cloned and used efficiently with an N-acetylhexosamine 1-kinase (NahK_ATCC55813) and an inorganic pyrophosphatase (PmPpA) for one-pot three-enzyme synthesis of UDP-GlcNAc derivatives with or without further chemical diversification.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11279325PMC
http://dx.doi.org/10.1039/c1cc14034eDOI Listing

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